DC Chemicals · Product datasheet

Belizatinib(TSR-011) — Datasheet

CAT. NO. DC10448

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ParameterValue
Chemical NameBelizatinib
CAS No.1357920-84-3
SynonymsBelizatinib;TSR-011;Belizatinib (TSR011);Z8A6022P3J;Belizatinib [INN];4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide;4-Fluoro-N-{(2e)-6-{[4-(2-Hydroxypropan-2-Yl)piperidin-1-Yl]methyl}-1-[cis-4-(Propan-2-Ylcarbamoyl)cyclohexyl]-1,3-Dihydro-2h-Benzimidazol-2-Ylidene}benzamide;4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-
FormulaC33H44FN5O3
M.Wt577.7326
SMILESFC1C([H])=C([H])C(=C([H])C=1[H])C(N([H])C1=NC2C([H])=C([H])C(=C([H])C=2N1C1([H])C([H])([H])C([H])([H])C([H])(C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(C([H])([H])[H])(C([H])([H])[H])O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

In Vitro

TSR-011 has antitumour activity in the clinical trials.

In Vivo

TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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