DCH-057Trigonelline
Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
View activity & pricesDC Chemicals · Research reagentsDCH-057 
DC7150
DC10475
DC10201
DC7375
DC8481
DC7319
DC5070
DC7299
DC7523
DC7130
DC26011
DC7734
DC5011
DC7239
DCAPI1436
DC11412
DC7586
DC7714
DC7454
DC7896
DC7885
DC7907
DC8118
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DC8738
DC7436
DC8167
DC7334
DC7229
DC7852
DC7975
DC10476
DC12384
DC9795
DC4232
DCY-155
DC9240
DC7174
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DC8139
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DC5147
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Small Molecule Research Tools
2816 products · Page 7 of 59
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DCH-057DC7150Birabresib (OTX015)
Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.
View activity & pricesDC10475Grapiprant
Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
View activity & pricesDC10201STK16-IN-1
STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
View activity & pricesDC7375BMS-303141
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
View activity & pricesDC8481Delanzomib(CEP-18770)
Delanzomib(CEP-18770) is a novel orally-active inhibitor of the chymotrypsin-like activity of the proteasome that down-modulates the nuclear factor-kappaB (NF-kappaB) activity.
View activity & pricesDC7319CCDC(TGR5-Receptor-Agonist)
TGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
View activity & pricesDC5070IOX2
IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM.
View activity & pricesDC7299SRPIN340
SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1.
View activity & pricesDC7523TTP22
TTP 22 is a potent CK2 inhibitor, with an IC50 of 100 nM and a Ki of 40 nM.
View activity & pricesDC7130GBR 12935 dihydrochloride
GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor.IC50 value: Target: dopamine reuptake inhibitorin vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935…
View activity & pricesDC26011GSK3145095
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
View activity & pricesDC7734CZC24832
CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC50=27 nM) with apparent dissociation constants (Kdapp) of 19 nM.
View activity & pricesDC5011UNC0631
UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM.UNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231…
View activity & pricesDC7239PluriSln 1(NSC 14613)
PluriSln 1 is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor.
View activity & pricesDCAPI1436Milbemycin oxime
Milbemycin oxime is a veterinary drug from the group of milbemycins, used as a broad spectrum antiparasitic.
View activity & pricesDC11412SR 0987
SR0987 is a RORγt agonist, with an EC50 of 800 nM.
View activity & pricesDC7586LDN-212854
LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other…
View activity & pricesDC7714Fenretinide (4-HPR)
Fenretinide is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
View activity & pricesDC7454LH846
LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
View activity & pricesDC7896ELR-510444
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell…
View activity & pricesDC7885NVP-TAE226
NVP-TAE 226 is a dual tyrosine kinase inhibitor of FAK (IC50=5.5 nM) and IGF-IR (mean IC50=0.14 μM).
View activity & pricesDC7907UNC2250
UNC2250 is a phosphorylation of endogenous Mer inhibitor with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein.
View activity & pricesDC8118GKT137831(Setanaxib)
GKT137831 is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
View activity & pricesDC8244wp1066（STAT Inhibitor III）
WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
View activity & pricesDC8738Sal003
Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation…
View activity & pricesDC7436JAK2 Inhibitor V,Z3
JAK2 Inhibitor V, Z3 is a cell-permeable pyridinylbutanone compound that inhibits both JAK2 and the active V167F mutant cellular autophosphorylation. JAK2 Inhibitor V, Z3 displays no effect against cellular Tyk 2…
View activity & pricesDC8167Onalespib（AT13387,ATI13387X）
AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. in vitro: AT13387 is a synthetic, orally bioavailable, small-molecule inhibitor of heat…
View activity & pricesDC7334UPF 1069
UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively.
View activity & pricesDC7229PF-4708671
PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.
View activity & pricesDC7852LRRK2 inhibitor GSK2578215A
GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.GSK2578215A exhibits exceptionally high selectivity for LRRK2 across the…
View activity & pricesDC7975CP 640186
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.
View activity & pricesDC10476NCGC00244536
NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.
View activity & pricesDC12384LF3
LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM.
View activity & pricesDC9795HA-15
HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading…
View activity & pricesDC4232Vismodegib (GDC-0449)
Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. It also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively.
View activity & pricesDCY-155Eupalinolide B
Eupalinolide B is a germacrane sesquiterpene isolated from Eupatorium lindleyanum. Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823 and HL-60 tumour cell lines[1].
View activity & pricesDC9240PS-47
PS-47 is available from DC Chemicals for laboratory research. Contact us for application-specific product information.
View activity & pricesDC7174AGI-6780
AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50 of 190±8.1 nM.
View activity & pricesDC12800BMS-927711(Rimegepant)
Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
View activity & pricesDC7054AM580
AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.
View activity & pricesDC8139GMX1778(CHS-828)
GMX1778(CHS-828) is a potent inhibitor of NAD+ biosynthesis enzyme NAMPT with IC50 <25 nM.
View activity & pricesDC7317TG101209
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.
View activity & pricesDC11415GSK2033
GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.
View activity & pricesDC5147Molibresib(I-BET-762）
GSK 525762A is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
View activity & pricesDC8792Pirfenidone(AMR69)
Pirfenidone is a drug used for the treatment of idiopathic pulmonary fibrosis. It inhibits FGFR, EGFR, PDGFR, TGF-β, thereby slowing tumor cell proliferation.
View activity & pricesDC7774Ripasudil(K-115)
Ripasudil (K-115) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively.
View activity & pricesDC8494Toceranib phosphate(SU 11654)
Toceranib phosphate is a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively.
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