JAK2 Inhibitor V,Z3

Biological Activity

JAK2 Inhibitor V, Z3 is a cell-permeable pyridinylbutanone compound that inhibits both JAK2 and the active V167F mutant cellular autophosphorylation. JAK2 Inhibitor V, Z3 displays no effect against cellular Tyk 2 autophosphorylation in COS cells or SRC in cell-free kinase assays. JAK2 Inhibitor V, Z3 suppresses the JAK2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients.For the detailed information of JAK2 Inhibitor V, the solubility of JAK2 Inhibitor V in water, the solubility of JAK2 Inhibitor V in DMSO, the solubility of JAK2 Inhibitor V in PBS buffer, the animal experiment (test) of JAK2 Inhibitor V, the cell expriment (test) of JAK2 Inhibitor V, the in vivo, in vitro and clinical trial test of JAK2 Inhibitor V, the EC50, IC50,and Affinity of JAK2 Inhibitor V, Please contact DC Chemicals.

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.