DC3153Ivabradine hydrochloride
Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
View activity & pricesDC Chemicals · Research reagentsDC3153 
DC5008
DC7228
DC7581
DC57110
DC1091
DC1086
DC10742
DC4106
DC9995
DC7978
DC8544
DC7614
DC7223
DC7147
DC5072
DC7225
DC6301
DC10131
DC7329
DC5064
DC7056
DC7458
DC9505
DC7660
DC7237
DC10811
DC9542
DC10610
DC5193
DC5068
DC5054
DC2105
DC1057
DC10130
DC5019
DC7049
DC22664
DC10868
DC10518
DC3160
DC7723
DC7574
DC2061
DC10874
DC7180
DC7692
DC8261
Small Molecule Research Tools
2816 products · Page 8 of 59
Browse 372 research categories
DC3153DC5008PP2(AGL 1879)
PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC50s of 4 and 5 nM for Lck and Fyn, respectively.
View activity & pricesDC7228PF-04691502
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR. PF-04691502 binds to human PI3Kα, β, δ, γ and mTOR with Kis of 1.8, 2.1, 1.6, 1.9 and 16 nM, respectively.
View activity & pricesDC7581WHI-P154
WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.
View activity & pricesDC57110MAT2A inhibitor-2
MAT2A inhibitor-2 is a methionine adenosyltransferase 2A (MAT2A) inhibitor.
View activity & pricesDC1091PF-299804 (Dacomitinib,PF-00299804)
Dacomitinib is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
View activity & pricesDC1086GW-9508
GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.IC50 value: 7.32 (pEC50) [1]Target:…
View activity & pricesDC10742Ferrostatin-1 (Fer-1)
Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.
View activity & pricesDC4106PF573228
PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for purified recombinant catalytic fragment of FAK.
View activity & pricesDC9995MGL-3196(Resmetirom)
MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM.
View activity & pricesDC7978Tucidinostat(Chidamide)
Chidamide is a synthetic benzamide-type HDAC inhibitor, inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 95, 160, 67 and 78 nM, respectively.
View activity & pricesDC8544MI-463
MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.
View activity & pricesDC7614IOX1
IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most…
View activity & pricesDC7223Palomid 529 (P529)
Palomid 529 is a potent inhibitor of mTORC1 and mTORC2 complexes.
View activity & pricesDC7147GZD824
GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. IC50 Value: 0.34/0.68 nM(Bce-Abl wt/T315I) [1]Target: Bcr-Abl in vitro: GZD824…
View activity & pricesDC5072Duvelisib (IPI-145, INK1197)
Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.
View activity & pricesDC7225Pelitinib (EKB-569; WAY-EKB 569)
Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.
View activity & pricesDC6301PLX-4720
PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf.
View activity & pricesDC10131BMS-986205(Linrodostat)
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
View activity & pricesDC7329Toceranib(SU 11654; PHA 291639)
Toceranib is a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively.
View activity & pricesDC5064Baricitinib (INCB28050, LY3009104)
Baricitinib is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
View activity & pricesDC7056AMG-208
AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.
View activity & pricesDC7458LY2608204
LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.IC 50 value: 42 nM (EC50)Target: glucokinasein vitro: LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration…
View activity & pricesDC9505Pifithrin-α (hydrobromide)
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis.
View activity & pricesDC7660Go 6983
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
View activity & pricesDC7237PJ34 HCl
PJ34 hydrochloride is an inhibitor of PARPl1/2 with IC50 of 110 nM and 86 nM, respectively.
View activity & pricesDC10811S23
S23 is a novel Selective Androgen Receptor Modulator(SARM)
View activity & pricesDC9542MPTP (hydrochloride)
MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease.
View activity & pricesDC10610CycLuc1(Luciferase substrate)
CycLuc1 is a brain penetrant luciferase substrate.
View activity & pricesDC5193Roxadustat(FG-4592)
Roxadustat (FG-4592) is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor developed for the treatment of anemia.
View activity & pricesDC5068Idelalisib (CAL-101,GS-1101)
Idelalisib (CAL-101) is a highly selective and potent p110δ inhibitor with an IC50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes.
View activity & pricesDC5054AZD1080
AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.
View activity & pricesDC2105Lovastatin (MK-803)
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
View activity & pricesDC1057Fidaxomicin (Dificid)
Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug; selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that…
View activity & pricesDC10130Glabridin
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor,…
View activity & pricesDC5019(+)-JQ1
(+)-JQ-1 is a BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)).
View activity & pricesDC7049AdipoRon
AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.
View activity & pricesDC22664Fezolinetant
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
View activity & pricesDC10868Cilofexor
Cilofexor is a farnesoid X receptor (FXR) agonist.
View activity & pricesDC10518KIN1148
KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.
View activity & pricesDC3160Montelukast Sodium
Montelukast sodium is a potent, selective CysLT1 receptor antagonist.
View activity & pricesDC7723OTS-964
OTS-964 is a potent TOPK inhibitor (IC50=28 nM), which inhibits TOPK kinase activity with high affinity and selectivity.
View activity & pricesDC7574FIPI
FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM, respectively.
View activity & pricesDC2061A-803467
A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently…
View activity & pricesDC10874GlyT2-IN-1(YODA 1)
GlyT2-IN-1 is a glycine transporters GLYT2 inhibitor.Target: GLYT2The Glycine Transporter GlyT2 Controls the Dynamics of Synaptic Vesicle Refilling in Inhibitory Spinal Cord Neurons. GlyT2-IN-1 is a novel agonist of…
View activity & pricesDC7180KN-93 Phosphate
KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50…
View activity & pricesDC7692Almorexant HCl (Act-078573)
Almorexant Hcl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
View activity & pricesDC8261(-)-JQ-1
(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.
View activity & prices