Ferrostatin-1 (Fer-1) chemical structure
Chemical structureResearch use only
CAT. NO. DC10742Featured

Ferrostatin-1 (Fer-1)

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TotalUS$400
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Product overview

Description & Application

Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

ParameterValue
Chemical NameEthyl 3-amino-4-(cyclohexylamino)benzoate
CAS No.347174-05-4
SynonymsEthyl 3-amino-4-(cyclohexylamino)benzoate;Ferrostatin-1 (Fer-1);ethyl 3-amino-4-cyclohexylaminobenzoate;Ferrostatin 1;Ferrostatin-1;3-amino-4-cyan-1-phenyl-pyrrol-2-carbonsaeureethylester;3-Amino-4-cyclohexylamino benzoic acid ethyl ester;3-amino-4-cyclohexylamino-benzoic acid ethyl ester;AC1LDIR8;AG-G-09537;CTK1E8332;ethyl 3-amino-4-cyano-1-phenyl-1H-pyrrole-2-carboxylate;HMS2445A21;Fer-1;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester;ferrostatin-1-fer-1;UJHBVMHOBZBWMX-UHFFFAOYSA-N;HMS3653M21;BCP17366;s7243;SB19587;SEL10496268;SEL10496253;ST45002378;SW2
FormulaC15H22N2O2
M.Wt262.3474
SMILESO(C([H])([H])C([H])([H])[H])C(C1C([H])=C([H])C(=C(C=1[H])N([H])[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

In Vitro

Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS[1]. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 µM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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