DC10728Pibrentasvir(ABT-530)
Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
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Small Molecule Research Tools
2816 products · Page 10 of 59
Browse 372 research categories
DC10728DC8066Loxiglumide
Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.
View activity & pricesDC8896Tiagabine hydrochloride
Tiagabine hydrochloride(NO328 hydrochloride) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.Tiagabine had an early onset of effect, as shown by significant reduction from baseline in mean HAM-A total…
View activity & pricesDC1099Trametinib
Trametinib is a potent MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Due to the poor solubility of Trametinib, Trametinib DMSO solvate (Cat. No.: HY-10999A) is recommeded.
View activity & pricesDC8001CPI 169 R-enantiomer
CPI-169, a representative compound from that effort, inhibits the catalytic activity of PRC2 with an IC50 of < 1nM, decreases cellular levels of H3K27me3 with an EC50 of 70 nM, and triggers cell cycle arrest and…
View activity & pricesDCAPI1502Lenalidomide
Lenalidomide is a potent inhibitor of TNF-α used as a immunomodulatory drug. It has also been shown to have anti-angiogenic properties.
View activity & pricesDC10379SDMA
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity.
View activity & pricesDC10627MSC2530818
MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8.
View activity & pricesDC8024T-5224
T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It also inhibits MMP3/13 with IC50s of 10 nM.
View activity & pricesDCD-031Oridonin
Oridonin, a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
View activity & pricesDC7039CFTR Inhibitor II
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
View activity & pricesDC5195Omecamtiv mecarbil (CK-1827452)
Omecamtiv mecarbil is a cardiac myosin activator.
View activity & pricesDC127035-Formyl-2-pyrimidinecarbonitrile
5-Formyl-2-pyrimidinecarbonitrile is a chemical intermidate..
View activity & pricesDCAPI1010Peramivir Trihydrate
Peramivir (RWJ 270201; Rapiacta; BCX 1812) is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.Peramivir is an experimental antiviral drug…
View activity & pricesDC7610LDN-57444
LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC50 of…
View activity & pricesDC7258Bemcentinib（R428，BGB324)
Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM.
View activity & pricesDC7037R306465(JNJ-16241199)
R306465, also known as JNJ-16241199, is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models.
View activity & pricesDC7647Ximelagatran
Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant…
View activity & pricesDC5014AVL-292
Spebrutinib (AVL-292; CC-292) is a covalent, orally active, and highly selective with an IC50 of 0.5 nM.
View activity & pricesDC5040Oclacitinib maleate
Oclacitinib(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM). IC50 value: 10 nM (JAK1) Target: JAKs in vitro: Oclacitinib…
View activity & pricesDC7837GW-3965 hydrochloride
GW3965 hydrochloride is a potent and selective LXR agonist with EC50s of 190 and 30 nM for hLXRα and hLXRβ , respectively.
View activity & pricesDC1075AZD4547
AZD4547 is a potent inhibitor of the FGFR family with IC50s of 0.2 nM, 2.5 nM, 1.8 nM, and 165 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
View activity & pricesDCAPI1476Ertapenem Sodium
Ertapenem sodium is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases.
View activity & pricesDC10754LX2343
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
View activity & pricesDC1036GSK-0660
GSK0660 is a potent antagonist of PPARβ and PPARδ, with IC50s of 155 nM for both isoforms.
View activity & pricesDC7842PD158780
PD158780 is a potent EGFR family inhibitor with IC50s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.
View activity & pricesDC7832KB-R7943 mesylate
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.
View activity & pricesDC7479Tiplaxtinin(PAI-039)
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.
View activity & pricesDCF-003Lycopene
Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.
View activity & pricesDC5007pp1
PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively.
View activity & pricesDC7344ZCL 278
ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with Kd of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.
View activity & pricesDC8338Azeliragon（PF-04494700,TTP488）
TTP488 is an antagonist at the Receptor for Advanced Glycation End products, is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD).
View activity & pricesDC7526Varespladib
LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM.IC50 value: 7 nMTarget: sPLA2in vitro: LY315920 exhibits the significant inhibitory…
View activity & pricesDC8304Isoxazole 9(ISX9)
ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells…
View activity & pricesDC6801Bindarit
Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.
View activity & pricesDC7141Omipalisib
Omipalisib (GSK2126458) is a highly selective and potent inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.
View activity & pricesDC5075BDP-12(Ampalex)
Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
View activity & pricesDC7931UNC2025
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by…
View activity & pricesDC8269NS6180
NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.
View activity & pricesDC7943LYS6K2(LY2584702) tosylate salt
LY-2584702 tosylate salt is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.
View activity & pricesDC7142GSK2606414
GSK2606414 is a cell-permeable and orally available PERK inhibitor with an IC50 of 0.4 nM.
View activity & pricesDC7167Capmatinib(INCB28060)
Capmatinib (INCB28060) is a potent and selective c-MET kinase inhibitor. Capmatinib (INCB28060) inhibits c-MET kinase activity with an average IC50 of 0.13 nM.
View activity & pricesDC7094Alpelisib(BYL-719)
Alpelisib (BYL-719) is a potent and selective PI3Kα inhibitor with an IC50 of 5 nM.
View activity & pricesDC77366H05
6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of…
View activity & pricesDC9701Tipifarnib
Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, and the anti-proliferative effects are most prominent in H-ras or N-ras mutant cells.
View activity & pricesDC7144GSK429286A
GSK429286A is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.
View activity & pricesStructure information available on request
DC5056AMD3465
AMD 3465 hexahydrobromide is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4…
View activity & pricesDC7570Z-VAD(OMe)-FMK
Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.
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