Isoxazole 9(ISX9) chemical structure
Chemical structureResearch use only
CAT. NO. DC8304Featured

Isoxazole 9(ISX9)

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Product overview

Description & Application

ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.

ParameterValue
Chemical NameN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
CAS No.832115-62-5
SynonymsN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide;Isoxazole 9;ISX 9;ISX-9;N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide
FormulaC11H10N2O2S
M.Wt234.2743
SMILESO=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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