DC9708Paxalisib (GDC-0084)
GDC-0084 is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.
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DC7171
DC8335
DC10617
DC7801
DC1056
Brain Cancer
6 products · Page 1 of 1
All small molecule research tools
DC9708DC7171INK-128(Sapanisertib)
Sapanisertib (INK-128) is a ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.
View activity & pricesDC8335PQR-309(Bimiralisib)
Bimiralisib is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. Bimiralisib is…
View activity & pricesDC10617CBL0137
CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. CBL0137 has broad anticancer activity in mice when administered orally, eradicates…
View activity & pricesDC7801LB-100
LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
View activity & pricesDC1056PD0325901 (Mirdametinib)
PD0325901 is a selective and cell permeable MEK inhibitor with an IC50 of 0.33 nM.
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