DC8124ETH 2120(Sodium ionophore III)
Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.
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DC59018
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Small Molecule Research Tools
2816 products · Page 58 of 59
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DC8124DC59018PLX5622 hemifumarate
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and…
View activity & pricesDC3105BMS-599626 (AC480)
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc
View activity & pricesDC7654GSK-J4 hydrochloride
GSK-J4 is a potent H3K27me3 histone lysine demethylase (KDM) inhibitor, with IC50s of 8.6 μM and 6.6 μM against KDM6B and KDM6A, respectively.
View activity & pricesDC8267SW033291
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
View activity & pricesDC10635MRT67307 HCl
MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively.
View activity & pricesDC7557Ulixertinib (BVD-523, VRT752271)
Ulixertinib (VRT752271) is a reversible, ATP-competitive inhibitor of ERK1 and ERK2 kinases, with IC50 of <0.3 nM against ERK2.
View activity & pricesDC10077WAY-200070
WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
View activity & pricesDC10528CP 376395
CP 376395 is a potent and selective Corticotropin releasing factor 1 (CRF1) receptor antagonist.
View activity & pricesDC10369TAS-102 (Trifluridine/tipiracil hydrochloride, 2:1)
Trifluridine-tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug that consists of an antineoplastic thymidine-based nucleoside analog, trifluorothymidine, and a potent thymidine phosphorylase…
View activity & pricesDC7300SRT1720 HCl
SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities on SIRT2 and SIRT3 with EC1.5s of 37 μM and 300 μM, respectively.
View activity & pricesDC7500Siramesine-hydrochloride
Siramesine(Lu 28-179) Hcl is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agentsiramesine…
View activity & pricesDC8409BRD7552
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.
View activity & pricesDC8565AVN944
AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2
View activity & pricesDC7265Rigosertib sodium
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.
View activity & pricesDC4102SB-269970
SB269970 is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
View activity & pricesDC7658C646
C646 is a selective and competitive histone acetyltransferase p300 inhibitor with Ki of 400 nM, and is less potent for other acetyltransferases.
View activity & pricesDC9545Miglustat hydrochloride
Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).Miglustat is an inhibitor of the ceramide-specific glycosyltransferase, which catalyzes the first…
View activity & pricesDC12174Deucravacitinib (BMS-986165)
Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).
View activity & pricesDC10328Migalastat hydrochloride
Migalastat hydrochloride (1-Deoxygalactonojirimycin hydrochloride) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.
View activity & pricesDC10522FIN56
FIN56 is a specific inducer of ferroptosis.
View activity & pricesDC7494SB 242084 dihydrochloride
IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonist
View activity & pricesDC10757PCI-29732
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.IC50 value: 8.2 nM [1]Target: Btk kinasePCI 29732(compound 1) has a 8.2 nM potency against Btk in…
View activity & pricesDC23187Nigericin sodium salt
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.
View activity & pricesDC10484NSC781406
NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.
View activity & pricesDC10079CYM-5541 (ML249)
CYM-5541 (ML249) is an selective and allosteric S1P3 receptor agonist with an EC50 between 72 and 132 nM.
View activity & pricesDC23125Pyrotinib dimaleate
Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 s of 13 and 38 nM, respectively.
View activity & pricesDC22335E3 ligase Ligand 1A ((S,R,S)-AHPC-Me)
E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer.
View activity & pricesDC8916Vanoxerine dihydrochloride
Vanoxerine dihydrochloride is a potent and selective dopamine reuptake inhibitor.
View activity & pricesDC4111Nolatrexed dihydrochloride (AG-337)
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1].…
View activity & pricesDC9383Rimonabant hydrochloride
Rimonabant hydrochloride is a cannabinoid receptor (CB) antagonist which binds selectively to CB1 with a Ki of 2 nM.
View activity & pricesDC7814Cerdulatinib (PRT062070; PRT2070)
Cerdulatinib (PRT062070) is a dual JAK and SYK inhibitor with IC50s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively.
View activity & pricesDC373976-Thioguanosine (2-Amino-6-mercaptopurin-9-ylriboside)
6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects.
View activity & pricesDCAPI1559Calcifediol
Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).
View activity & pricesDC22608GBR 12935 (free base)
GBR 12935 is a potent, and selective dopamine reuptake inhibitor.
View activity & pricesDC24191Cyclophosphamide monohydrate
Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
View activity & pricesDC42585RHI002
HIV inhibitor, showing selective activity against human RNaseH2
View activity & pricesDC8231LDN-192960 dihydrochloride
LDN-192960 is a potent Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor with an IC50 of 0.010 µM.
View activity & pricesDC21033Trilaciclib dihydrochloride (G1T28)
Trilaciclib hydrochloride is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively.
View activity & pricesDC8041MK-0941
MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in…
View activity & pricesDC7985RU 24969 hemisuccinate
RU 24969 hemisuccinate is a potent SR-1A/SR-1B and moderate SR-2C agonist that may also release serotonin.
View activity & pricesDC8759Thiamet G
Thiamet-G is a potent and selective inhibitor of OGA, which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
View activity & pricesDC3162Eszopiclone
Eszopiclone (Lunesta) along with other "Z-drugs" including zolpidem (Ambien), zaleplon (Sonata) are the most commonly prescribed sedative hypnotics in the USA. Eszopiclone is not marketed in the European Union…
View activity & pricesDC42510Ivacaftor-d9
Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog…
View activity & pricesDC9163Ibutilide fumarate
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm.Ibutilide is the first 'pure' class III…
View activity & pricesDC26119VHL ligand 2 hydrochloride ((S,R,S)-AHPC-Me hydrochloride)
VHL ligand 2 hydrochloride is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.
View activity & pricesDC24178Moxifloxacin
A fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria; inhibits DNA gyrase and topoisomerase IV.Bacterial InfectionApproved
View activity & pricesDC70103MS.001
MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
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