DC Chemicals · Research reagents

Thyrotropin Receptor

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ML-224 chemical structureDC7781

ML-224

ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM.

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Org 274179-0 chemical structureDC73510

Org 274179-0

Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.

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