Org 274179-0 chemical structure
Chemical structureResearch use only
CAT. NO. DC73510Featured

Org 274179-0

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TotalUS$650
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Product overview

Description & Application

Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.

ParameterValue
Chemical NameOrg 274179-0
CAS No.1421683-12-6
FormulaC28H27F3N2O2
M.Wt480.53
SMILESO=C(NC1=CC2=C(N(C(C)=O)CC[C@@]2(C)C3=CC=CC=C3)C=C1)CCC4=CC=CC(C(F)(F)F)=C4
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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