Chemical structureResearch use only

CAT. NO. DC7781Featured

ML-224

Name: ML-224
Brand: DC Chemicals
SKU: DC7781
Price: 850.0 USD

Pack Sizes & Prices

TotalUS$850

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Product overview

Description & Application

ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM.

Parameter	Value
Chemical Name	NCGC00242364，ANTAG3，ML-224，ML 224
CAS No.	1338824-21-7
Synonyms	NCGC00242364，ANTAG3，ML-224，ML 224
Formula	C31H31N3O5
M.Wt	525.59
SMILES	C1=C(NC(=O)C)C=C(C)C(OCC2=C(OC)C=CC(C3NC4C=CC=CC=4C(=O)N3CC3=CC=CO3)=C2)=C1C
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ML224(NCGC00242364; ANTAG3) is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM.

In Vitro

ANTAG3 was selective for TSHR inhibition; half-maximal inhibitory doses were 2.1 μM for TSHR and greater than 30 μM for LH and FSH receptors [2].

In Vivo

In mice treated with TRH, ANTAG3 lowered serum free T4 by 44% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 75% and 83%, respectively. In mice given M22, ANTAG3 lowered serum free T4 by 38% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 73% and 40%, respectively [2].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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