Fibrosis

5 products · Page 1 of 1

All small molecule research tools

DC9278

CWHM-12

CWHM-12 is a potent inhibitor of αV integrins with IC50s of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1.

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DC4128

Ivacaftor (VX-770)

Ivacaftor is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.

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DC10459

BMS-986020

BMS-986020 is an LPA1 antagonist.target: LPA1BMS-986020 is in Phase 2 clinical development for treating idiopathic pulmonary fibrosis. BMS-986020 selectively inhibits the LPA receptor, which is involved in binding of…

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DC11803

GLPG-1690(Ziritaxestat)

GLPG1690 is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and Ki of 15 nM.

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DC10390

TD139

TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM.

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