DC11385Trofinetide(NNZ2566)
Trofinetide, a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.
View activity & pricesDC Chemicals · Research reagentsDC11385 
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Small Molecule Research Tools
2816 products · Page 51 of 59
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DC11385DC70440GPS167
GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and…
View activity & pricesDC11647JNJ-2408068
JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ 2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum…
View activity & pricesDC29105Epithalon
Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases…
View activity & pricesDC10311Allopregnanolone
Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor.
View activity & pricesDCAPI1211L-Thyroxine
For the detailed information of L-Thyroxine, the solubility of L-Thyroxine in water, the solubility of L-Thyroxine in DMSO, the solubility of L-Thyroxine in PBS buffer, the animal experiment（test） (test) of…
View activity & pricesDC10182Elacestrant (dihydrochloride)
Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.
View activity & pricesDC11579VH032
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.
View activity & pricesDC70095NSD1 inhibitor BT5
1. Huang H, et al. Nat Chem Biol. 2020 Dec;16(12):1403-1410. Chemical & Physical Properties
View activity & pricesDC73953CPAG-1
CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2. CPAG-1 treatment had no effect on weight or food intake but treated mice had reduced fasting glycemia and insulin levels. CPAG-1 decreased…
View activity & pricesDC32395Niraparib tosylate hydrate
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
View activity & pricesDC9772Efinaconazole(KP-103)
Efinaconazole(KP-103) is a novel triazole antifungal drug currently under development as a topical treatment for onychomycosis.
View activity & pricesDC72592Zelasudil
Zelasudil is a Rho-associated (ROCK) kinase inhibitor. Zelasudil has a ROCK2 binding affinity.
View activity & pricesDC49692T-Type calcium channel inhibitor(TTA-P2)
T-Type calcium channel inhibitor is a potent inhibitor of T-Type calcium channel. T-Type calcium channel inhibitor penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the…
View activity & pricesDC6560042-(2-Tetrazolyl)rapamycin
42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.
View activity & pricesDC9755eFT508(Tomivosertib)
eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms.
View activity & pricesDC60493BEBT-809
BEBT-809 is a GPR75 antagonist for rat CYP4F2 and CYP4A11 with IC50 of and 15.76 nM and 33.16 nM, respectively.
View activity & pricesDC70862UC-764865
UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell…
View activity & pricesDC4115Cyclosporin A
Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM.
View activity & pricesDC202976-Hydroxy-DL-DOPA
6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer[1].
View activity & pricesDC7182Dacinostat (NVP-LAQ824, LAQ824)
Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.
View activity & pricesDC8441Nitenpyram
For the detailed information of Nitenpyram, the solubility of Nitenpyram in water, the solubility of Nitenpyram in DMSO, the solubility of Nitenpyram in PBS buffer, the animal experiment (test) of Nitenpyram, the cell…
View activity & pricesDC36924NNMTi
NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[1]. NNMTi promotes myoblast differentiation in vitro and enhances…
View activity & pricesDC9774LEE011 succinate
Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
View activity & pricesDCAPI1242Isoniazid(Tubizid)
Isoniazid is an antibacterial agent used primarily as a tuberculostatic.Target: AntibacterialIsoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG…
View activity & pricesDCC0593Sotorasib racemate
Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib, a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor…
View activity & pricesDC71430NHS-NH-(diethylamino)ethyl benzoate
NHS-NH-(diethylamino)ethyl benzoate is a compound that can be used for N-glycan labeling.
View activity & pricesDC70935ZHAWOC21026
ZHAWOC21026 is a highly potent, host-specific small-molecule inhibitor of paramyxovirus (Canine distemper virus, CDV IC50=3.2 nM) and pneumovirus (RSV, IC50=31 nM) replication.
View activity & pricesDC46535THK-5475(THK 5475)
THK-5475(THK5475) is a precursor of THK-5470, a monoamine oxidase-B(MAO-B) imaging probe, could be used for neurological diseases study (from patent EP2019-846498).
View activity & pricesDCAPI1491Celecoxib
Celecoxib is a selective COX-2 inhibitor with an IC50 of 40 nM.
View activity & pricesDC70478HDAC3 inhibitor PT3
HDAC3 inhibitor PT3 is a novel potent, selective, BBB-permeable HDAC3 inhibitor.PT3 exhibited higher selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8 compared to the reference compound CI994.PT3 upregulated H3K9…
View activity & pricesStructure information available on request
DC73064NACE2i
NACE2i is a cell permeable, specific and selective peptide inhibitor of nuclear ACE2, inhibits binding between IMP1α and ACE2 and SARS-CoV-2 viral replication. NACE2i specifically targets nuclear ACE2 and not other…
View activity & pricesDC26059Diprotin A
Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.1 μg/ml).It inhibits degradation of glucagon-like peptide 1 in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells when used…
View activity & pricesDC70459GSK3011724A
GSK 3011724A (DG-167, GSK-3011724A) is a potent, specific inhibitor of β-ketoacyl-ACP synthase (KasA, Kd=9 nM), shows anti-tubercular activity (MIC H37Rv=0.8 uM); shows much weaker apparent dissociation constant for…
View activity & pricesDC60607SL-25.1188
SL-25.1188 is a reversible MAO-B inhibitor with high brain uptake and slow plasma metabolism, making it a promising candidate for treating Alzheimer's dementia and aiding in smoking cessation. Its ability to modulate…
View activity & pricesDC34176SW203668
SW203668 is a potent, tumor-specific inhibitor of stearoyl CoA desaturase (SCD) with better bioavailability than SW208108.
View activity & pricesDC70209AS105
AS105 (AS-105) is a highly potent, ATP-competitive CaMKII inhibitor, inhibits CaMKIIδ with IC50 of 8 nM, Ki of 3 nM. AS105 is also effective against autophosphorylated CaMKII (in contrast to the commonly used…
View activity & pricesDC46349ALS-I
ALS-I, an acid-Liable surfactant, is adopted for in-solution enzymatic digestions, can help to solubilize hydrophobic proteins. ALS-I is significantly enhanced peptide recovery for mass spectrometry (MS) mapping in the…
View activity & pricesDC60622KM822
KM822 is avselective, noncompetitive modulator of human dopamine transporter (DAT) with IC50 3.7 μM, which shows 30 and 50 folds higher than for human norepinephrine transporter (hNET) and human serotonin transporter…
View activity & pricesDC9147Aripiprazole
Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.Aripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA…
View activity & pricesDC60781TRPC6 activator compound 2
TRPC6 activator compound 2 is selective activator of TRPC6 that does not potentiate TRPC3 and mTRPC7. Comp2 is able to cross BBB.
View activity & pricesDC37947Chloroquine
Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require…
View activity & pricesDC73322DP308
DP308 is a novel and effective 53BP1 tandem Tudor domain (TTD) inhibitor, disrupts the binding between 53BP1 and H4K20me2 peptide with IC50 of 1.69 uM.
View activity & pricesDC9131Nimodipine
Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and…
View activity & pricesDCAPI1182Azathioprine (Azasan, Imuran)
For the detailed information of Azathioprine (Azasan, Imuran), the solubility of Azathioprine (Azasan, Imuran) in water, the solubility of Azathioprine (Azasan, Imuran) in DMSO, the solubility of Azathioprine (Azasan,…
View activity & pricesDC4226Moxifloxacin hydrochloride
For the detailed information about the solubility of Moxifloxacin hydrochloride in water, the solubility of Moxifloxacin hydrochloride in DMSO, the solubility of Moxifloxacin hydrochloride in PBS buffer, the animal…
View activity & pricesDCAPI1397Orlistat (Alli, Xenical)
For the detailed information of Orlistat (Alli, Xenical), the solubility of Orlistat (Alli, Xenical) in water, the solubility of Orlistat (Alli, Xenical) in DMSO, the solubility of Orlistat (Alli, Xenical) in PBS…
View activity & pricesDC31537Amisulpride
Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. In Italy, it is also used as a treatment for dysthymia. It was introduced by Sanofi-Aventis…
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