Cyclosporin A chemical structure
Chemical structureResearch use only
CAT. NO. DC4115Featured

Cyclosporin A

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Product overview

Description & Application

Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM.

ParameterValue
Chemical NameCyclosporin A
CAS No.59865-13-3
SynonymsCyclosporin A;Cyclosporin A (Cyclosporine ,Antibiotic S 7481F1,Ciclosporin A, Ramihyphin A,CsA);Cyclosporin A solution;CYCLOSPORIN A, TOLYPOCLADIUM INFLATUM;Cyclosporine;Cyclosporine A;Atopica;ciclosporin;ciclosporin A;Cipol N;Cyclosporin A from Tolypocladium inflatum;Cyclosporine Resolution Mixture;Neoplanta;Neoral;ol27-400;Optimmune;Restasis;s7481f1;sandimmun;sandimmun neoral;Sandimmun optoral;Cyclosporin;Antibiotic S 7481F1;Ciclosporine;Ciclosporinum;Ciclosporina;Sandimmune;Equoral;Gengraf;Consupren;Ramihyphin A;SangCyA;83HN0GTJ6D;MLS001333756;CSA;S-Neoral;Sigmasporin Microoral;Sang 35;DSSTox_CID_365;Ciclosporinum [INN-Latin];Ciclosporine [INN-French];Ciclosporina [INN-Spanish];DSSTox_RID_75541;Ciclosporin (Ciclo
FormulaC62H111N11O12
M.Wt1202.6113
SMILESO([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])/C(/[H])=C(\[H])/C([H])([H])[H])[C@@]1([H])C(N([H])[C@]([H])(C(N(C([H])([H])[H])C([H])([H])C(N(C([H])([H])[H])[C@]([H])(C(N([H])[C@]([H])(C(N(C([H])([H])[H])[C@]([H])(C(N([H])[C@@]([H])(C([H])([H])[H])C(
Purity99%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM.

In Vitro

Cyclosporin A is able to bind with the cyclophilin in T cells[1]. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin[2]. Cyclosporin A exhibits inhibitory effect on calcineurin with an IC50 of 7 nM[3]. Cyclosporin A suppresses the nuclear translocation of NF-AT[4]. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM[5].

In Vivo

Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs[6]. Cyclosporin A can be used in organ transplantation to prevent rejection[7].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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