PT-179 chemical structure
Chemical structureResearch use only
CAT. NO. DC60559Featured

PT-179

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TotalUS$350
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Product overview

Description & Application

PT-179 is a new orthogonal immunomodulatory drug (IMiD) derivative that binds CRBN but does not induce degradation of off-target proteins. PT-179 potently degrades proteins fused to SD40 at either the N or C terminus.

ParameterValue
Chemical NamePT-179
CAS No.2924858-25-1
Synonyms2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-
FormulaC17H17N3O5
M.Wt343.333984136581
SMILESO=C1C2=CC(N3CCOCC3)=CC=C2C(N1C1CCC(NC1=O)=O)=O
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

PT-179 is a new orthogonal immunomodulatory drug (IMiD) derivative that binds CRBN but does not induce degradation of off-target proteins. PT-179 potently degrades proteins fused to SD40 at either the N or C terminus.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

Continuous evolution of compact protein degradation tags regulated by selective molecular glues-Science . 2024 Mar 15;383(6688):eadk4422. doi: 10.1126/science.adk4422. Epub 2024 Mar 15.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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