Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.1 μg/ml).It inhibits degradation of glucagon-like peptide 1 in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells when used at a concentration of 25 μM.Diprotin A (5 mg/ml) pre-incubation enhances chemotaxis of murine embryonic stem cells towards stromal cell-derived factor-1 (SDF-1/CXCL12) in vitro.Pre-incubation of CD34+ human umbilical cord blood cells with diprotin A (5 mM) prior to injection increases engraftment in NOD/SCID recipient mice.
Parameter
Value
Chemical Name
Diprotin A
CAS No.
90614-48-5
Synonyms
L-Isoleucine,L-isoleucyl-L-prolyl-;DiprotinA;H-Ile-Pro-Ile-OH;ILE-PRO-ILE;DIPEPTIDYLPEPTIDASE IV INHIBITOR I;H-ILE-PRO-ILE-OH H2O;ILE-PRO-ILE H2O;Ile-Pro-Ile-OH;L-Ile-L-Pro-L-Ile-OH;L-Isoleucyl-L-prolyl-L-isoleucine;Diprotin A;Ile-Pro-Ile;L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)- (ZCI);L-Isoleucyl-L-prolyl-L-isoleucine (ACI);3: PN: JP2011182742 SEQID: 3 unclaimed protein;JNTMAZFVYNDPLB-PEDHHIEDSA-N;Dipeptidyl peptidase IV inhibitor;isoleucylprolylisoleucine;BSPBio_003515;SMP1_000085;NCGC00178015-01;(2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidine-5-carboxamido)-3-methylpentanoic acid;BDBM50229666;BCBcMAP01_000164;CHEMBL214381;L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)-;CS-0034521;Spectrum2_001480;CHEBI:93213;BRD-K69032158-001-02-2;IPI;AKOS030210980;SCHEMBL6404766;HY-111174;90614-48-5;Spectrum3_001838;DTXSID80920277;(2S,3S)-2-[[[(2S)-1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-methylpentanoic acid;MFCD00038707;N-(1-L-Isoleucyl-L-prolyl)-L-isoleucine;N-[Hydroxy(1-isoleucylpyrrolidin-2-yl)methylidene]isoleucine;MS-25221;CCG-38872;l-isoleucyl-l-prolyl-l-isoleucine;Diprotin A (H-L-Ile-L-Pro-L-Ile-OH);isoleucyl-prolyl-isoleucine;Diprotin A (Ile-Pro-Ile);(2S,3S)-2-((S)-1-((2S,3S)-2-Amino-3-methylpentanoyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid;SPBio_001439;KBio3_003020;diprotin A;Q27164930
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological Activity
Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.1 μg/ml).It inhibits degradation of glucagon-like peptide 1 in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells when used at a concentration of 25 μM.Diprotin A (5 mg/ml) pre-incubation enhances chemotaxis of murine embryonic stem cells towards stromal cell-derived factor-1 (SDF-1/CXCL12) in vitro.Pre-incubation of CD34+ human umbilical cord blood cells with diprotin A (5 mM) prior to injection increases engraftment in NOD/SCID recipient mice.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.
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