DC Chemicals · Product datasheet

Diprotin A — Datasheet

CAT. NO. DC26059

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ParameterValue
Chemical NameDiprotin A
CAS No.90614-48-5
SynonymsL-Isoleucine,L-isoleucyl-L-prolyl-;DiprotinA;H-Ile-Pro-Ile-OH;ILE-PRO-ILE;DIPEPTIDYLPEPTIDASE IV INHIBITOR I;H-ILE-PRO-ILE-OH H2O;ILE-PRO-ILE H2O;Ile-Pro-Ile-OH;L-Ile-L-Pro-L-Ile-OH;L-Isoleucyl-L-prolyl-L-isoleucine;Diprotin A;Ile-Pro-Ile;L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)- (ZCI);L-Isoleucyl-L-prolyl-L-isoleucine (ACI);3: PN: JP2011182742 SEQID: 3 unclaimed protein;JNTMAZFVYNDPLB-PEDHHIEDSA-N;Dipeptidyl peptidase IV inhibitor;isoleucylprolylisoleucine;BSPBio_003515;SMP1_000085;NCGC00178015-01;(2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidine-5-carboxamido)-3-methylpentanoic acid;BDBM50229666;BCBcMAP01_000164;CHEMBL214381;L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)-;CS-0034521;Spectrum2_001480;CHEBI:93213;BRD-K69032158-001-02-2;IPI;AKOS030210980;SCHEMBL6404766;HY-111174;90614-48-5;Spectrum3_001838;DTXSID80920277;(2S,3S)-2-[[[(2S)-1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-methylpentanoic acid;MFCD00038707;N-(1-L-Isoleucyl-L-prolyl)-L-isoleucine;N-[Hydroxy(1-isoleucylpyrrolidin-2-yl)methylidene]isoleucine;MS-25221;CCG-38872;l-isoleucyl-l-prolyl-l-isoleucine;Diprotin A (H-L-Ile-L-Pro-L-Ile-OH);isoleucyl-prolyl-isoleucine;Diprotin A (Ile-Pro-Ile);(2S,3S)-2-((S)-1-((2S,3S)-2-Amino-3-methylpentanoyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid;SPBio_001439;KBio3_003020;diprotin A;Q27164930
FormulaC17H31N3O4
M.Wt341.445744752884
SMILESC(N1CCC[C@H]1C(=O)N[C@H](C(=O)O)[C@@H](C)CC)(=O)[C@@H](N)[C@@H](C)CC
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.1 μg/ml).It inhibits degradation of glucagon-like peptide 1 in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells when used at a concentration of 25 μM.Diprotin A (5 mg/ml) pre-incubation enhances chemotaxis of murine embryonic stem cells towards stromal cell-derived factor-1 (SDF-1/CXCL12) in vitro.Pre-incubation of CD34+ human umbilical cord blood cells with diprotin A (5 mM) prior to injection increases engraftment in NOD/SCID recipient mice.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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