DC5184Epirubicin HCl (4'-epidoxorubicin)
Epirubicin (hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase.
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DC4188
DC7905
DC8852
DC5905
DC7530
DC8111
DC10410
DC8325
DCAPI1566
Topoisomerase
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All small molecule research tools
DC5184DC4188Doxorubicin hydrochloride
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of…
View activity & pricesDC7905beta-Lapachone (ARQ-501, CO-501)
Beta-Lapachone inhibits DNA relaxation induced by DNA topoisomerase I in a dose-dependent manner. Treatment of beta-lapachone (100 nM or greater) results in >95% inhibition of Topo I DNA unwinding activity compared to…
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DC8934Irinotecan
Irinotecan is a water soluble topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.
View activity & pricesDC8852SW-044248
SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines.
View activity & pricesDC5905SN-38(NK-012)
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
View activity & pricesDC7530Voreloxin
Voreloxin is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
View activity & pricesDC8111Idarubicin Hydrochloride
Idarubicin hydrochloride is an anthracycline antileukemic drug. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription.
View activity & pricesDC10410Ellipticine hydrochloride
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
View activity & pricesDC8325Ellipticine
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
View activity & pricesDCAPI1566Cytarabine hydrochloride
For the detailed information of Cytarabine hydrochloride, the solubility of Cytarabine hydrochloride in water, the solubility of Cytarabine hydrochloride in DMSO, the solubility of Cytarabine hydrochloride in PBS…
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