DC12702A1874
A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation[1].
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Small Molecule Research Tools
2816 products · Page 38 of 59
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DC12702DC7085BIBR-1532
BIBR 1532 is a potent, selective and non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay.
View activity & pricesDC22301ZB716(Fulvestrant-3 Boronic Acid)
ZB716 is a steroidal, orally bioavailable SERD (selective estrogen receptor downregulator) that binds to ER with high affinity and exerts its antiestrogenic effect on ER-expressing breast cancer cells.
View activity & pricesDC4124ROSCOVITINE(Seliciclib)
Roscovitine is a potent and selective CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.
View activity & pricesDC7648PNU159682
PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a potent ADCs cytotoxin.
View activity & pricesDC12022dBET6
dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC50 of 14 nM, and has antitumor activity.
View activity & pricesDC10316Cenicriviroc
Cenicriviroc is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
View activity & pricesDC3130ICG-001
ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. It works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM.
View activity & pricesDC22871MS-402
MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell…
View activity & pricesDC53051PF07104091(Tagtociclib)
PF-07104091 is an orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity. Upon administration, CDK2 inhibitor PF-07104091 selectively targets, binds to and inhibits…
View activity & pricesDC9746RSL3
RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.
View activity & pricesDC39004A1120
A 1120 is a high affinity non-retinoid ligand for retinol-binding protein 4 (RBP4) with the ki value of 8.3 nM[1].
View activity & pricesDC9646Ingenol
Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.
View activity & pricesDC70729Ral inhibitor 1
Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras; Ral inhibitor 1…
View activity & pricesDC28012c-Di-AMP(Cyclic-Di-AMP) ammonium salt
Cyclic-di-AMP (c-di-AMP) is a second messenger molecule produced in bacteria but not in mammals; can induce a strong immune response in vitro and in vivo.
View activity & pricesDC10327Calcitonin salmon
Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption. Sequence:…
View activity & pricesDC45570Tirzepatide (LY3298176)
Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.
View activity & pricesDC9569Nefazodone (hydrochloride)
Nefazodone hydrochloride is an antidepressant drug.
View activity & pricesDC10652HG-14-10-04
HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.IC50 value: 20 nMTarget: ALKMore information can be found in the following Patent, Example 10Preparation of substituted pyrimidinamines as ALK…
View activity & pricesDC27000SPR741 (NAB741)
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative…
View activity & pricesDC1069AZD6244 (Selumetinib,ARRY-142886)
Selumetinib is a highly potent MEK inhibitor, with an IC50 of 14 nM against MEK1.
View activity & pricesDC5055Plerixafor (AMD3100)
Plerixafor is a selective CXCR4 antagonist with an IC50 of 44 nM.
View activity & pricesDC8223TP-0903
TP-0903 is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM.
View activity & pricesDC39113Gartisertib
Gartisertib (VX-803) is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an…
View activity & pricesDC70203ARN23746(IAMA-6)
ARN 23746 (ARN-23746) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows NKCC1 inhibition 31.8% at 10 uM, and 95.2% at 100 uM in the Cl− influx assay on NKCC1-transfected HEK293 cells.ARN23746 did not…
View activity & pricesDC21981CD73 inhibitor AB-680
AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39.…
View activity & pricesDC800212-(Aminooxy)ethanamine dihydrochloride
2-(Aminooxy)ethanamine (dihydrochloride) is a PROTAC linker that can be used in the synthesis of PROTACs.
View activity & pricesDC47683Mesdopetam hemitartrate
Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research…
View activity & pricesDC10864C188-9
C188-9 is a Stat3 inhibitor, with a Kd of 4.7 nM.
View activity & pricesDC12578IMTPPE
IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells; IMTPPE inhibited proliferation of…
View activity & pricesDC8764AR 231453
AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent.
View activity & pricesDC23129Senexin B
Senexin B is a potent, highly water-soluble and bioavailable CDK8/19 inhibitor, with Kds of 140 nM for CDK8 and 80 nM for CDK19.
View activity & pricesDC35688Azidoacetic acid NHS ester
Azidoacetic acid NHS ester is a compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to…
View activity & pricesDC4184Vinorelbine Ditartrate
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
View activity & pricesDC70801SRX3305
SRX 3305 is a potent, triple BTK/PI3K/BRD4 inhibitor with IC50 of 6.5 nM, 15 nM, and 4 nM toward BTK, PI3Kɑ and PI3Kδ respectively, inhibits BRD4 BD1 and BD2 with IC50 of 77 and 95 nM.SRX3305 showed enhanced binding to…
View activity & pricesDC10661Takinib
Takinib is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM.
View activity & pricesDC39025FOY-251
FOY 251 free base is an anti-proteolytic active metabolite camostate (HY-13512), acts as a proteinase inhibitor[1].
View activity & pricesDC7780ZM241385
ZM 241385 is a selective and high affinity A2A adenosine receptor antagonist.
View activity & pricesDC7372Bazedoxifene-Acetate
Bazedoxifene acetate is a third generation selective estrogen receptor modulator (SERM) with IC50s of 26 and 99 nM for ERα and ERβ, respectively.
View activity & pricesDC22137LGD2226
LGD-2226 is a selective and orally active androgen receptor modulator with an EC50 of 0.2 nM and a Ki of 1.5 nM for human androgen receptor. LGD-2226 shows tissue selectivity in animal models, with reduced effects on…
View activity & pricesDC45762Y-27632
Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively.
View activity & pricesDC9912Echinocystic acid
Echinocystic acid a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, has potent antioxidant, anti-inflammatory and anti-tumor properties. In vitro: Echinocystic acid (EA) inhibit the formation…
View activity & pricesDC49970ZYS-1
Fludarabine-Cl has inhibition effect on RNA adenosine deaminase 1(ADAR1), and can be used for preventing and/or treating cancer or tumor-related diseases[1].
View activity & pricesDC8809Bedaquiline fumarate
Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.
View activity & pricesDC33090ONO-8130
ONO-8130 is an orally available EP1 receptor antagonist.
View activity & pricesDC8198RTA-408(Omaveloxolone)
RTA-408 is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO).
View activity & pricesDC70273BT173
BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway.BT173 disrupts HIPK2-Smad3 protein-protein interaction (PPI) without significant inhibition of…
View activity & pricesDC28198RHC 80267
RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the…
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