CD73 inhibitor AB-680 chemical structure
Chemical structureResearch use only
CAT. NO. DC21981Featured

CD73 inhibitor AB-680

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Product overview

Description & Application

AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

ParameterValue
Chemical NameCID 130205852
CAS No.2105904-82-1
SynonymsJ6K8WSV73A;GTPL10707;AB680;[[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid;(((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid;CID 130205852 AB 680
FormulaC20H24ClFN4O9P2
M.Wt580.824889183044
SMILESClC1C([H])=C(C2C([H])=NN(C=2N=1)[C@@]1([H])[C@@]([H])([C@@]([H])([C@@]([H])(C([H])([H])OP(C([H])([H])P(=O)(O[H])O[H])(=O)O[H])O1)O[H])O[H])N([H])[C@@]([H])(C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

In Vitro

AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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