DC10841VAS 2870
VAS2870 is a NADPH oxidase (NOX) inhibitor.
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Small Molecule Research Tools
2816 products · Page 36 of 59
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DC10841DC32766Idalopirdine Hydrochloride
Idalopirdine, also known as Lu AE58054 or Iladopirdine, is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated…
View activity & pricesDC58055P300/CBP-IN-3
P300/CBP-IN-3, a p300/CBP histone acetyltransferase inhibitor, Compound 6, is sourced from patent WO 2019049061 A1[1].
View activity & pricesDC30001VU6015929
VU6015929 is a selective discoidin domain receptor inhibitor. VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production, suggesting DDR1 inhibition as an exciting target for antifibrotic…
View activity & pricesDC34338Pyrintegrin
Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.…
View activity & pricesDC42750BI-749327
BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse…
View activity & pricesDC21765TVB-3166
TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces…
View activity & pricesDC8022R-268712
R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
View activity & pricesDC5902Emtricitabine
For the detailed information of Emtricitabine, the solubility of Emtricitabine in water, the solubility of Emtricitabine in DMSO, the solubility of Emtricitabine in PBS buffer, the animal experiment（test） (test) of…
View activity & pricesDC11349Histrelin acetate
Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor).
View activity & pricesDC7485PTC-209
PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM.
View activity & pricesDC60643BRD-810
BRD-810 is a potent and selective MCL1 inhibitor with Kd of 0.3 nM (SPR) and IC50 of 0.4 nM (MCL1-Noxa HTRF), respectively. BRD-810 is a rapidly cleared inhibitor of MCL1 that has robust antitumor efficacy in…
View activity & pricesDC8351Avibactam sodium
Avibactam sodium is a covalent and reversible β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
View activity & pricesDC65716Daraxonrasib（RMC-6236）
RAS-IN-2 (Compound A122) is a potent RAS(ON)MULTI inhibitor and can be used for the research of cancer.
View activity & pricesDC4169ASC-J9
For the detailed information about the solubility of ASC-J9 in water, the solubility of ASC-J9 in DMSO, the solubility of ASC-J9 in PBS buffer, the animal experiment（test） of ASC-J9, the in vivo,in vitro and clinical…
View activity & pricesDC10360MLi-2
MLi-2 is an a potent, highly selective, orally available, brain penetrant inhibitor of LRRK2 with an IC50 of 0.76 nM.
View activity & pricesDC4146Roflumilast
Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
View activity & pricesDC8761BMS-345541
BMS-345541 is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
View activity & pricesDC9615SR3335
SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the…
View activity & pricesDC7398DDR1-IN-1
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinaseinhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM).
View activity & pricesDC11516Balovaptan
Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
View activity & pricesDC11504GeA-69
GeA-69 is a selective, highly cell permeable allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2, with a Kd of 2.1 µM[1].
View activity & pricesDC7050ADL5859 HCl
ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. IC50 value: 0.8 nM(Ki)Target: δ-opioid receptorADL-5859 (ADL5859) is…
View activity & pricesDC22092Imidazole ketone erastin（IKE）
Imidazole ketone erastin (IKE) s a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.
View activity & pricesDC580624-Nitrophenylrhamnoside
4-Nitrophenyl α-L-rhamnopyranoside is a chromogenic substrate for naringinase.
View activity & pricesDC9808APS-2-79 hydrochloride
APS-2-79 hydrochloride behaves as a kinase suppressor of Ras (KSR)-dependent antagonist of RAF-mediated MEK phosphorylation. APS-2-79 binds directly to KSR2 within the KSR2-MEK1 complex with an IC 50 of 120±23 nM for…
View activity & pricesDC26208Remdesivir metabolite(GS-441524)
GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM.
View activity & pricesDC58305DALDA
DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) is a potent μ-opioid peptide agonist, affecting various patterns of locomotor activities.
View activity & pricesDC11197UoS12258
UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6; displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and…
View activity & pricesDC22136LEI 110
LEI110 (LEI－110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6); reduces cellular arachidonic acid levels and oleic…
View activity & pricesDC10447FX1
FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.
View activity & pricesDC23203E4CPG
E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .
View activity & pricesDC20903ML401 (CID73169083)
ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].
View activity & pricesDC10406Imisopasem manganese
M40403 is a small molecule, synthetic manganese containing superoxide dismutase mimetic (SODm) that removes superoxide anions without interfering with other reactive species known to be involved in inflammatory…
View activity & pricesDC10139Stat5 Inhibitor(STAT5-IN-1)
Stat5 Inhibitor(STAT5-IN-1) is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
View activity & pricesDC8059PF 429242
PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) that reduces expression levels of hepatic SREBP target genes and lower rates of…
View activity & pricesDC47315ML-SI3
ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.
View activity & pricesDC1067KU-55933
KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
View activity & pricesDC40118Giredestrant
Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change…
View activity & pricesDC9043Pramipexole 2HCL monohydrate
Pramipexole dihydrochloride hydrate is a selective dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole…
View activity & pricesDC40567Alkyne tyramide
Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne tyramide substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate…
View activity & pricesDC10530BLU-285 (Avapritinib)
Avapritinib is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V.
View activity & pricesDC8181Filanesib(ARRY-520)
Filanesib (ARRY-520) is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
View activity & pricesDC32380Elexacaftor
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 (compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell…
View activity & pricesDC51795-IODOTUBERCIDIN
5-Iodotubercidin (Itu) has been shown to inhibit mitogen-activated protein kinase (ERK2) (Ki = 525 nM), adenosine kinase (ADK) (Ki = 30 nM), casein kinases 1 & 2 (CSNK1A1 & CSNK2A1), protein kinase A (PKA) and insulin…
View activity & pricesDC50012TLR7/8 agonist 1 dihydrochloride
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline.
View activity & pricesDC12581MDI-2268
MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and…
View activity & pricesDC39091IM156
IM156, a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156…
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