ML401 (CID73169083) chemical structure
Chemical structureResearch use only
CAT. NO. DC20903Featured

ML401 (CID73169083)

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TotalUS$550
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Product overview

Description & Application

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].

ParameterValue
Chemical Name(E)-3-(4-bromophenyl)-1-(4-(4-chlorobenzyl)-piperazin-1-yl)prop-2-en-1-one
CAS No.1597489-14-9
SynonymsCID73169083; ML-401;ML 401;CID 73169083;CID-73169083
FormulaC20H20BrClN2O
M.Wt419.747
SMILESC1CN(CCN1CC2=CC=C(C=C2)Cl)C(=O)/C=C/C3=CC=C(C=C3)Br
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].

In Vitro

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1].

In Vivo

ML401 shows very good stability in both human plasma and mouse plasma[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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