ML-SI3 chemical structure
Chemical structureResearch use only
CAT. NO. DC47315Featured

ML-SI3

Pack Sizes & Prices

TotalUS$400
We match the best price and quality on market.
Product overview

Description & Application

ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.

ParameterValue
Chemical NameN-{2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide
CAS No.891016-02-7
FormulaC23H31N3O3S
M.Wt429.575544595718
SMILESCOC1C=CC=CC=1N1CCN(C2CCCCC2NS(C2C=CC=CC=2)(=O)=O)CC1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

Related research products

Clemizole Hydrochloride chemical structureDC7387

Clemizole Hydrochloride

Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.

View activity & prices
SB-705498 chemical structureDC9635

SB-705498

SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.

View activity & prices
SB-366791 chemical structureDC9735

SB-366791

SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM. SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent…

View activity & prices
GDC-0334 chemical structureDC70430

GDC-0334

GDC-0334 (GDC0334) is a highly potent, selective, orally bioavailable TRPA1 antagonist with IC50 of 1.7 nM in cell-based assays.GDC-0334 demonstrated potent TRPA1 inhibition in several species, including human…

View activity & prices
AMG9810 chemical structureDC10132

AMG9810

AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

View activity & prices
HC-067047 chemical structureDC11416

HC-067047

HC-067047 is a potent and selective TRPV4 antagonist with IC50s of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4.

View activity & prices
TRPC6-PAM-C20 chemical structureDC45287

TRPC6-PAM-C20

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 selectively activates TRPC6 over other TRP channels and also activates TRPA1. TRPC6-PAM-C20 induces transient increase in intracellular…

View activity & prices

Cart

Request quotation