DC9836Mivebresib(ABBV-075）
Mivebresib is a potent and orally available bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.
View activity & pricesDC Chemicals · Research reagentsDC9836 
DC1054
DCAPI1512
DC8469
DC8021
DC8380
DC10832
DC9879
DC9983
DC9272
DC5107
DCAPI1510
DC7704
DC3126
DC8301
DC11329
DC9268
DC8248
DC6909
DC8265
DC10153
DC7276
DC2060
DC1102
DC10182
DC7211
DC5067
DC3143
DC5150
DC3105
Breast Cancer
30 products · Page 1 of 1
All small molecule research tools
DC9836DC1054GDC0941(Pictilisib)
GDC-0941 (Pictilisib) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
View activity & pricesDCAPI1512Lapatinib
Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50s of 10.2 and 9.8 nM, respectively.
View activity & pricesDC8469Palbociclib
Palbociclib (PD 0332991) is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer.
View activity & pricesDC8021Indoximod (NLG-8189)
Indoximod (D-1MT, NLG8189) is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki of 19 μM.
View activity & pricesDC8380AZD8186
AZD8186 is a PI3K inhibitor, which potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC5050=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
View activity & pricesDC10832(E/Z)-4-hydroxy Tamoxifen
(E/Z)-4-Hydroxytamoxifen is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is an estrogen receptor modulator.
View activity & pricesDC9879AZD8835
AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50s of 6.2 and 5.7 nM, respectively.
View activity & pricesDC9983E-7449
E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ∼50 and ∼50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
View activity & pricesDC9272K 858
K858 Racemic is an ATP-uncompetitive inhibitor of Eg5 with an IC50 of 1.3 μM.
View activity & pricesDC5107SB-715992 (Ispinesib)
Ispinesib is a specific inhibitor of KSP, with a Ki app of 1.7 nM.
View activity & pricesDCAPI1510Ixabepilone
Ixabepilone is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and…
View activity & pricesDC7704Poziotinib
Poziotinib(NOV120101; HM781-36B) is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.
View activity & pricesDC3126BMS754807
BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor (IGF-1R)/insulin receptor family kinases (IR) with IC50 of 1.8 and 1.7 nM, respectively and Ki of <2 nM for both, and also…
View activity & pricesDC8301Elacridar
Elacridar is a potent P-glycoprotein (Pgp) and BCRP inhibitor.
View activity & pricesDC11329Fadrozole (hydrochloride)
Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
View activity & pricesDC9268AZD9496
AZD9496 is a potent and selective estrogen receptor (ERα) antagonist with an IC50 of 0.28 nM.
View activity & pricesDC8248Ostarine(MK-2286)
Ostarine(MK-2866; GTX-024) is a modulator of human androgen receptor.IC50 value:Target: androgen receptorOstarine (MK-2866) is an androgen receptor modulator (SARM) with an ED50 of 0.44 mg/day. Ostarine (MK-2866) has…
View activity & pricesDC6909Entinostat (MS-275)
Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively.
View activity & pricesDC8265Endoxifen
Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen inhibits hERG…
View activity & pricesDC10153GDC-0077
GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I.
View activity & pricesDC7276Saracatinib (AZD0530)
Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk and shows high selectivity over other tyrosine kinases.
View activity & pricesDC2060CI994 (Tacedinaline)
CI-994 (Tacedinaline) is an inhibitor of the histone deacetylase (HDAC) with IC50s of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively.
View activity & pricesDC1102Tariquidar (XR9576)
Description of Tariquidar: Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter,…
View activity & pricesDC10182Elacestrant (dihydrochloride)
Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.
View activity & pricesDC7211Neratinib (HKI-272)
Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.
View activity & pricesDC5067Palbociclib (PD0332991 HCl)
Palbociclib hydrochloride is a highly selective CDK4/6 inhibitor with IC50s of 11 nM and 16 nM, respectively.
View activity & pricesDC3143Lapatinib ditosylate monohydrate
Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM,…
View activity & pricesDC5150Veliparib dihydrochloride (ABT-888 dihydrochloride)
Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.
View activity & pricesDC3105BMS-599626 (AC480)
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc
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