DC7392CW069
CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM.
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Small Molecule Research Tools
2816 products · Page 20 of 59
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DC7392DC7884LY310762
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.IC50 value: 249 nM (Ki) [1]Target: 5-HT1D in vitro: LY310762 has a higher affinity for the guinea pig 5-HT1D…
View activity & pricesDC8657R112
R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM.
View activity & pricesDC7886TTNPB
TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
View activity & pricesDC9928VU 0364770
VU0364770 is an allosteric of metabotropic glutamate receptor 4 (mGlu4) modulator, which exhibits a EC50 of 1.1±0.2 μM at human mGlu4.
View activity & pricesDC10135AR-7
AR7 is a retinoic acid receptor α (RARα) antagonist.
View activity & pricesDC10127UNC569
UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo.
View activity & pricesDC7353ABT-751(E 7010)
ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.
View activity & pricesDC7291GSK650394
GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively.
View activity & pricesDC10373WEHI-345
WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.
View activity & pricesDCAPI1495Aliskiren Hemifumarate
Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.
View activity & pricesDC7052AG-1024 (Tyrphostin)
AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.
View activity & pricesDC10149TM5275 sodium salt
TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 μM.
View activity & pricesDC10148SBC-110736
SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1, Figure 1.
View activity & pricesDC7113CZC-25146
CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
View activity & pricesDC7718B-Raf IN 1
B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.
View activity & pricesDC7977Nicaraven
Nicaraven is a novel chemically synthesized hydroxyl radical-specific scavenger.
View activity & pricesDC10122Apoptozole
Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
View activity & pricesDC10468Tyrphostin AG-555
AG 555 is an EGFR tyrosine kinase inhibitor.
View activity & pricesDC8471CGS 21680 hydrochloride
CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
View activity & pricesDC5012AZD-1208
AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor.
View activity & pricesDC7868AS703026（Pimasertib）
Pimasertib (AS703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2, used for cancer treatment.
View activity & pricesDC7976CID 797718
CID-797718 is a compound with unknown details. For the detailed information of CID 797718, the solubility of CID 797718 in water, the solubility of CID 797718 in DMSO, the solubility of CID 797718 in PBS buffer, the…
View activity & pricesDC9955BCL6 inhibitor(CID5721353)
CID5721353 is an inhibitor of BCL6 with an IC50 value of 212 μM, which corresponds to a Ki of 147 μM.
View activity & pricesDC10128FGF401( Roblitinib)
FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.
View activity & pricesDC9856NS638
NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4 μM.
View activity & pricesDC1007510074-G5
10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.
View activity & pricesDC9693Madrasin
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell…
View activity & pricesDC9459SB 415286
SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.
View activity & pricesDC8158Pexidartinib(PLX3397)
Pexidartinib (PLX-3397) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13 nM, 27 nM, and 11 nM for CSF1R, c-Kit, and FLT3, respectively.
View activity & pricesDC9260Eptapirone
F 11440 is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.Target: 5-HT1AThe affinity of F 11440 for 5-HT1Abinding sites (pKi, 8.33) was higher than that…
View activity & pricesDC8836NIBR189
NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).NIBR189 is a potent and selective EBI2 antagonist with improved…
View activity & pricesDC8822MSX-122
MSX-122 is a partial antagonist of CXCR4, inhibiting CXCR4/CXCL12 actions, with an IC50 of ∼10 nM; MSX-122 has anti-inflammatory and anti-metastatic activity.
View activity & pricesDC8747PD 151746
PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).
View activity & pricesDC7234PIK-294
PIK-294 is a potent p110δ-selective inhibitor with an IC50 of 10 nM.
View activity & pricesDCAPI1393Nedaplatin (Aqupla)
Nedaplatin is a derivative of cisplatin and DNA damage agent.Target: OthersNedaplatin(NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the…
View activity & pricesDC8334RS-127445
RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel…
View activity & pricesDC8890Imidafenacin
Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).IC50 value: 0.3 nM(M3) [1]in vitro: KRP-197 showed equipotent anti-M2…
View activity & pricesDC86491-Methyl-7-nitroisatoic anhydride
1-methyl-7-nitroisatoic anhydride is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.
View activity & pricesDC4125PHA-739358 (danusertib)
Description of Danusertib: Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Aurora kinase inhibitor PHA-739358 binds to and inhibits the Aurora kinases, which may result…
View activity & pricesDC9672NSC5844 (RE640)
NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.
View activity & pricesDC78767ACC2
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT…
View activity & pricesDC8329SLx-2119(KD-025,Belumosudil )
SLx-2119 is a selective inhibitor of ROCK2 with an IC50 of 105 nM.
View activity & pricesDC9503MI 2 (MALT1 inhibitor)
MI 2 (MALT1 inhibitor) is an irreversible MALT1 protease inhibitor with an IC50 of 5.84 μM.
View activity & pricesDC6911pardoprunox (SLV308)
Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist; D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A…
View activity & pricesDC8068WHI-P180(Janex 3)
WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibits RET, KDR and EGFR with IC50s of 5 nM, 66 nM and 4 μM, respectively.
View activity & pricesDC8490SM-164
SM-164 is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP.
View activity & pricesDC8834HZ-1157
HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].
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