CW069 chemical structure
Chemical structureResearch use only
CAT. NO. DC7392Featured

CW069

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TotalUS$400
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Product overview

Description & Application

CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM.

ParameterValue
Chemical Name(S)-2-(2-(Benzylamino)-3-phenylpropanamido)-5-iodobenzoic acid
CAS No.1594094-64-0
SynonymsCW 069;CW069;(S)-2-(2-(Benzylamino)-3-phenylpropanamido)-5-iodobenzoic acid;C23H21IN2O3;AOB2368;BCP27898;s7336;2342AH;SB19453;SW219359-1;A13735;2-[(2S)-2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO]-5-IODOBENZOIC ACID;benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-;CW-069
FormulaC23H21IN2O3
M.Wt500.3289
SMILESIC1C([H])=C([H])C(=C(C(=O)O[H])C=1[H])N([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM.

In Vitro

CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM. CW-069 shows statistically significant selectivity over KSP. CW-069 potently suppresses N1E-115 cells, and less potently inhibits the NHDF cells, with IC50 of 86 ± 10 μM and 181 ± 7 μM, respectively. CW-069 (100 or 200 μM) causes increased multipolar spindles in N1E-115 cells with supernumerary centrosomes and shows no effect on altering bipolar spindle morphology in normal human dermal fibroblast cells. CW-069 (200 μM) cacuses multipolar anaphase and cell death induced in N1E-115 cells via transfection with HSET siRNA, and antagonizes inhibition of KSP by monastrol, but does not exert mitotic arrest in HeLa cells[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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