DC Chemicals · Product datasheet

CW069 — Datasheet

CAT. NO. DC7392

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ParameterValue
Chemical Name(S)-2-(2-(Benzylamino)-3-phenylpropanamido)-5-iodobenzoic acid
CAS No.1594094-64-0
SynonymsCW 069;CW069;(S)-2-(2-(Benzylamino)-3-phenylpropanamido)-5-iodobenzoic acid;C23H21IN2O3;AOB2368;BCP27898;s7336;2342AH;SB19453;SW219359-1;A13735;2-[(2S)-2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO]-5-IODOBENZOIC ACID;benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-;CW-069
FormulaC23H21IN2O3
M.Wt500.3289
SMILESIC1C([H])=C([H])C(=C(C(=O)O[H])C=1[H])N([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM.

In Vitro

CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM. CW-069 shows statistically significant selectivity over KSP. CW-069 potently suppresses N1E-115 cells, and less potently inhibits the NHDF cells, with IC50 of 86 ± 10 μM and 181 ± 7 μM, respectively. CW-069 (100 or 200 μM) causes increased multipolar spindles in N1E-115 cells with supernumerary centrosomes and shows no effect on altering bipolar spindle morphology in normal human dermal fibroblast cells. CW-069 (200 μM) cacuses multipolar anaphase and cell death induced in N1E-115 cells via transfection with HSET siRNA, and antagonizes inhibition of KSP by monastrol, but does not exert mitotic arrest in HeLa cells[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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