Chemical structureResearch use only

CAT. NO. DC9672Featured

NSC5844 (RE640)

Name: NSC5844 (RE640)
Brand: DC Chemicals
SKU: DC9672
Price: 550.0 USD

Pack Sizes & Prices

TotalUS$550

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Product overview

Description & Application

NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.

Parameter	Value
Chemical Name	NSC 5844; NSC-5844; RE 640; RE-640; RE640
CAS No.	140926-75-6
Synonyms	NSC 5844; NSC-5844; RE 640; RE-640; RE640
Formula	C20H16Cl2N4
M.Wt	383.27
SMILES	C1=CC2=C(C=CN=C2C=C1Cl)NCCNC3=C4C=CC(=CC4=NC=C3)Cl
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.

In Vitro

NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively[1]. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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