Chemical structureResearch use only

CAT. NO. DC11871Featured

MMV019313

Name: MMV019313
Brand: DC Chemicals
SKU: DC11871
Price: 450.0 USD

Pack Sizes & Prices

TotalUS$450

We match the best price and quality on market.

Product overview

Description & Application

MMV019313 (MMV 019313, MMV-019313) is a potent, specific malaria bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) inhibitor with IC50 of 330 nM; shows no activity against human FPPS or GGPPS (>200 uM); exhibits distinct modes of inhibition compared with bisphosphonates, inhibits P. falciparum growth with EC50 of 268 nM, overexpression and an S228T variant of PfFPPS/GGPPS confer resistance to MMV 019313.

Parameter	Value
Chemical Name	N-[3-(azepan-1-yl)propyl]-5-methyl-4-oxothieno[3,2-c]quinoline-2-carboxamide
CAS No.	902630-14-2
Synonyms	MMV 019313;MMV-019313
Formula	C22H27N3O2S
M.Wt	397.537
SMILES	N(C)1C2=C(C=CC=C2)C2SC(C(NCCCN3CCCCCC3)=O)=CC=2C1=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Gisselberg JE, et al. Cell Chem Biol. 2017 Dec 15. pii: S2451-9456(17)30427-0. View Related Products by Target Parasite

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheet Request COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

Related research products

DC10495

KAI407

KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing…

View activity & prices

DC7691

PF 1022A

PF 1022A is a N-methylated cyclooctadepsipeptides (CODPs) with strong anthelmintic properties; acts as an ionophore.PF 1022A showed strong anthelmintic activities against Ascaridia galli in chickens [1]. PF1022A is a…

View activity & prices

DC9672

NSC5844 (RE640)

NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.

View activity & prices

DC10258

Mebendazole

Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby…

View activity & prices

DC11886

Adavivint

Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.

View activity & prices

DC5090

WZ4002

WZ4002 is a mutant selective EGFR inhibitor with IC50s of 2, 8, 3 and 2 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750 and EGFRE746_A750/T790M, respectively.

View activity & prices

DC7146

GW788388

GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

View activity & prices