Biological Activity
MMV019313 (MMV 019313, MMV-019313) is a potent, specific malaria bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) inhibitor with IC50 of 330 nM; shows no activity against human FPPS or GGPPS (>200 uM); exhibits distinct modes of inhibition compared with bisphosphonates, inhibits P. falciparum growth with EC50 of 268 nM, overexpression and an S228T variant of PfFPPS/GGPPS confer resistance to MMV 019313.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
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References & source
References 1. Gisselberg JE, et al. Cell Chem Biol. 2017 Dec 15. pii: S2451-9456(17)30427-0. View Related Products by Target Parasite
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.