B-Raf IN 1 chemical structure
Chemical structureResearch use only
CAT. NO. DC7718Featured

B-Raf IN 1

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Product overview

Description & Application

B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.

ParameterValue
Chemical NameB-RafIN1
CAS No.950736-05-7
SynonymsB-RafIN1;BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-;B-Raf IN 1
FormulaC29H24F3N5O
M.Wt515.52897644043
SMILESO=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.

In Vitro

B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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