DC1105Linagliptin (BI-1356)
Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
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Small Molecule Research Tools
2816 products · Page 53 of 59
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DC1105DC65801ARV-102
ARV-102 is a highly potent, orally bioavailable PROTAC that targets LRRK2 with a of 0.14 nM, designed to cross the blood-brain barrier to address neurodegenerative diseases. By hijacking the body’s ubiquitin-proteasome…
View activity & pricesDC53057BPH-1358
BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro…
View activity & pricesDC67722Eloralintide sodium
Eloralintide (LY 3841136) sodium is an AMYR agonist, which is promising for research of type 2 diabetes and obesity.
View activity & pricesDC1096PIK90
PIK-90 is a DNA-PK and PI3K inhibitor, which inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
View activity & pricesDC8243Pimecrolimus
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.Pimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function [1].…
View activity & pricesDC2103Gefitinib (ZD1839)
Gefitinib (ZD1839) is a EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.
View activity & pricesDC100374μ8C
4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.
View activity & pricesDC10996DDR inhibitor X
DDR Inhibitor X is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.
View activity & pricesDC7435J-147
J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in…
View activity & pricesDC8440Erythromycin Cyclocarbonate
Erythromycin Cyclocarbonate, derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms.
View activity & pricesDC8578L002(NSC764414)
L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300…
View activity & pricesDC70312CLC-2-IN AK42
CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2).AK42 displays unprecedented selectivity (>1,000-fold)…
View activity & pricesDC7270Ro 31-8220 mesylate
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1,…
View activity & pricesDC9082Chlorpromazine HCl
Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel andsodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.
View activity & pricesDC11273Murepavadin (POL7080)
Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa. Bacterial Infection Phase 3 Clinical
View activity & pricesDC40111Protease K
Protease K is a nonspecific serine protease that is useful for general digestion of proteins. Protease K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures.
View activity & pricesDC8093TCS JNK 5a(JNK Inhibitor IX)
TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.
View activity & pricesDC2098Sorafenib (BAY-43-9006)
Sorafenib tosylate is a potent multikinase inhibitor, with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
View activity & pricesDC28041BIOTIN-PEG4-SBP1(spike-binding peptide 1)
Biotin modification of SBP1.SBP1(spike-binding peptide 1) is a first-in-class peptide binder to the SARS-CoV-2 spike protein. SBP1 specifically binds SARS-CoV-2-RBD with low nanomolar affinity. SBP1 to the RBD was…
View activity & pricesDC9809APS-3-77 HCl
APS-3-77 is the negative binder of KSR2.
View activity & pricesDC3144Nilotinib
Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
View activity & pricesDC7467ML-098
ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.
View activity & pricesDC1056PD0325901 (Mirdametinib)
PD0325901 is a selective and cell permeable MEK inhibitor with an IC50 of 0.33 nM.
View activity & pricesDC21329MLS 0263839
MLS 0263839 is a potent, specific inhibitor of the phosphatase PHOSPHO1 with IC50 of 0.14 uM, shows minimal cross-inhibition of TNAP and no inhibition of ENPP1 activity; suppresses vascular smooth muscle cell…
View activity & pricesDC9773LEE011 hydrochloride
Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
View activity & pricesDC8149Pemetrexed disodium
Pemetrexed disodium is a novel antifolate that inhibits the folatedependent enzymes thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase with Kis of 1.3, 7.2, and 65 nM,…
View activity & pricesDC9153Losartan Potassium
Losartan (potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
View activity & pricesDC10798p38-α MAPK-IN-1
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
View activity & pricesDC10236Sildenafil
Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
View activity & pricesDC10959STING inhibitor C-178
C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but…
View activity & pricesDC12577AC-263093
AC-263093 (AC263093) is a potent, functionally selective neuropeptide FF receptor type 2 (NPFFR2) agonist with pKi of 6.9; shows equal affinity for NPFFR1 and NPFFR2, and functionally inactivated NPFFR1; attenuates…
View activity & pricesDC26048GLS1 Inhibitor
GLS1 inhibitor is an inhibitor of glutaminase 1
View activity & pricesDC26219Protease-activated receptor 2 (PAR2) agonist(SLIGKV-NH2)
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.
View activity & pricesDC21685BVT-948
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8.
View activity & pricesDC22145MF-766
MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full…
View activity & pricesDC51011IXA6
IXA6 is a novel small molecule compound of inducing IRE1 RNase activity.
View activity & pricesDC23748ML372
ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of…
View activity & pricesDC12552PGN9856
PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a…
View activity & pricesDC51012IXA4
IXA4 is the most selective for the IRE1–XBP1s signaling pathway.IXA4 selectively activate IRE1–XBP1s signaling and reduces secretion of APP through IRE1 activation.
View activity & pricesDC20311Apraglutide
A peptidic glucagon like peptide 2 (GLP-2) analogue for treatment of type2 diabetes.
View activity & pricesDC26016Safinamide mesylate
Safinamide mesylate mesylate (FCE 26743 mesylate; EMD 1195686 mesylate) is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide mesylate also…
View activity & pricesDC22946ML-T531
ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM; exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1,…
View activity & pricesDC11857BAY-8040 (R)
Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related…
View activity & pricesDC58063HG106
HG106 is a potent SLC7A11 inhibitor and enhances ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD).
View activity & pricesDC70442GRK6 inhibitor 18
GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM. GRK6 inhibitor 18 displays >1,000-fold selectivity over Aurora A, as well as high selectivity against a panel of 85 kinases. GRK6 inhibitor…
View activity & pricesDC9742Ponesimod
Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator.
View activity & pricesDCAPI1325Rifabutin (Mycobutin)
For the detailed information of Rifabutin (Mycobutin), the solubility of Rifabutin (Mycobutin) in water, the solubility of Rifabutin (Mycobutin) in DMSO, the solubility of Rifabutin (Mycobutin) in PBS buffer, the…
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