Chemical structureResearch use only

CAT. NO. DC58063Featured

HG106

Name: HG106
Brand: DC Chemicals
SKU: DC58063
Price: 480.0 USD

Pack Sizes & Prices

TotalUS$480

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Product overview

Description & Application

HG106 is a potent SLC7A11 inhibitor and enhances ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD).

Parameter	Value
Chemical Name	Acetamide, 2-chloro-N -[2-(4-methoxyphenyl)-2H -benzotriazol-5-yl]- (ACI)
CAS No.	928712-10-1
Synonyms	HG-106, HG 106
Formula	C15H13ClN4O2
M.Wt	316.74
SMILES	O=C(NC=1C=CC2=NN(N=C2C1)C3=CC=C(OC)C=C3)CCl
Purity	>98%
Storage	-20

Biological Activity

HG106 is a potent SLC7A11 inhibitor and enhances ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD).

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma Kewen Hu, … , Mingyao Liu, Xiufeng Pang J Clin Invest. 2020;130(4):1752-1766. https://doi.org/10.1172/JCI124049.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

-20

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