DC74356ACA22
ACA22 is a small molecule KRAS inhibitor, inhibits KRAS-mediated signal transduction in cells expressing wild type (WT) and G12D mutant KRAS.
View activity & pricesDC Chemicals · Research reagentsDC74356 
DC7344
DC7736
DC8816
DC39083
DC26136
DC40333
DC70729
DC70371
DC70046
DC10725
DC7793
DC78346
DC7467
DC58063
DC74355
DC8725
Ras
17 products · Page 1 of 1
All small molecule research tools
DC74356DC7344ZCL 278
ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with Kd of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.
View activity & pricesDC77366H05
6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of…
View activity & pricesDC8816ARS-853
ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 μM.
View activity & pricesDC39083BI-3406(SOS1-IN-2)
BI-3406(SOS1-IN-2) is a Son of Sevenless 1 (SOS1) inhibitor extracted from patent WO2018115380A1, compound I-6, and it has an IC50 of 6 nM[1].
View activity & pricesDC26136MRTX849(Adagrasib)
MRTX849 is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. MRTX849 covalently binds to KRAS G12C at the cysteine at residue 12, locks the…
View activity & pricesDC40333APS6-45
APS6-45 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity.
View activity & pricesDC70729Ral inhibitor 1
Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras; Ral inhibitor 1…
View activity & pricesDC70371DW0254
DW0254 (DW-0254,DW 0254) is a small molecules capable of inhibiting RAS-related C3 botulinum toxin substrate (RAC) small GTPase activation in ALL cell lines, directly binds to the hydrophobic pocket of PDE6D (Kd=436…
View activity & pricesDC70046MRTX 0902
MRTX0902 is a potent SOS1 inhibitor with an IC50 of 46 nM (WO2021127429A1; Example 12-10).
View activity & pricesDC10725ARS-1620
ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
View activity & pricesDC7793K RAS INHIBITOR-12
K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.Binding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts…
View activity & pricesDC78346AH001
AH001 is a orally active RhoA inhibitor, which binds a cryptic pocket proximate to GDP within RhoA with a KD of 73.16 nM. AH001 interacts with GDP, stabilizing RhoA’s interaction with its endogenous inhibitor, RhoGDIα.…
View activity & pricesDC7467ML-098
ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.
View activity & pricesDC58063HG106
HG106 is a potent SLC7A11 inhibitor and enhances ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD).
View activity & pricesDC74355ACA-14
ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.
View activity & pricesDC8725NSC 23766 trihydrochloride
NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
View activity & prices