DC9819Guanoclor
Guanoclor is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.
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Small Molecule Research Tools
2816 products · Page 27 of 59
Browse 372 research categories
DC9819DC7067KPT-330(Selinexor)
KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor.IC50 value: Target: CRM1in vitro: As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL…
View activity & pricesDC7471N6022
N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC50 of 8 nM.
View activity & pricesDC10658OSS-128167(SIRT6-IN-1)
OSS_128167 is a selective SIRT6 inhibitor with IC50s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
View activity & pricesDC7613STATTIC
Stattic is a potent inhibitor of STAT3 activation and dimerization.
View activity & pricesDC21288MK-8617
MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
View activity & pricesDC9835Cytochalasin H
Cytochalasin H is a potent inhibitor of actin incorporation into filaments,a cell-permeable fungal toxin used in actin polymerization studies and cytological research. Cytochalasin H suppresses the production of…
View activity & pricesDC11420AS-1517499
AS1517499 is a potent STAT6 inhibitor with an IC50 of 21 nM.
View activity & pricesDC10006RSV-604
RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.IC50 value: 0.86 uM(EC50) [1]Target: RSV inhibitorRSV604, a…
View activity & pricesDC7029SC-26196
SC-26196 is a potent, orally active Delta6 desaturase (D6D) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties[1].
View activity & pricesDC8468Ceralasertib (AZD6738)
AZD6738 is a potent inhibitor of ATR kinase with an IC50 of 1 nM.
View activity & pricesDC11471BGB-3111(Zanubrutinib)
Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.
View activity & pricesDC7801LB-100
LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
View activity & pricesDC12443LASV inhibitor 3.3
LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells; does not inhibits…
View activity & pricesDC9965UNC3866
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.
View activity & pricesDC1006OSI-027
OSI-027 is an ATP-competitive mTOR kinase activity inhibitor with an IC50 of 4 nM. OSI-027 targets both mTORC1 and mTORC2 with IC50s of 22 nM and 65 nM, respectively.
View activity & pricesDC10471GSK-872
GSK'872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM.
View activity & pricesDC10125CZ415
CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex.
View activity & pricesDC7256Purvalanol B(NG-95)
Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
View activity & pricesDC9287D-Luciferin
D-luciferin is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.
View activity & pricesDC8783NS 9283
NS9283 is a positive positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors. NS9283 can be used in a series of neurological conditions such as attention deficit hyperactivity disorder (ADHD),…
View activity & pricesDC10783PF-9366
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.
View activity & pricesDC7368AZD5363
Capivasertib (AZD5363) is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
View activity & pricesDC10437MRE-269
MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
View activity & pricesDC7553SGC-0946
SGC 0946 is over 100-fold selective For other histone methyltransferases/HMTs. SGC 0946 potently reduces H3K79 dimethylation with IC50 of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells, which potently and selectively…
View activity & pricesDC21748TG693
TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
View activity & pricesDC10508Lys05
Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.
View activity & pricesDC10397Proguanil
Proguanil is an antimalarial prodrug that is metabolized to the active metabolite cycloguanil, a dihydrofolate reductase (DHFR) inhibitor.
View activity & pricesDC9394LDC000067
LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro.
View activity & pricesDC9330AIM-100
AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM.AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase [1].The Ack1…
View activity & pricesDC7114Dinaciclib (SCH727965)
Dinaciclib is a potent inhibitor of CDK, with IC50s of 1, 1, 3, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.
View activity & pricesDC7018LGX-818(Encorafenib)
Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
View activity & pricesDC21695Elamipretide (TFA salt)
Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide.
View activity & pricesDC9806S-2765(FXa substrate,Z-D-Arg-Gly-Arg-pNA Dihydrochloride)
S-2765, which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405…
View activity & pricesDC10630ONO-7300243
ONO-7300243 is a novel, potent lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 μM.
View activity & pricesDC7743Mdivi-1
Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor.
View activity & pricesDC88351-Methoxy PMS
1-Methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.1-Methoxy PMS can induce active oxygen formation.
View activity & pricesDC23161GDC-0810
GDC-0810 is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.
View activity & pricesDC10619UCPH-101
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.
View activity & pricesDC28013Cyclic-di-GMP(c-di-GMP)
Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
View activity & pricesDC93735-TAMRA
The amine-reactive 5-TAMRA, SE and its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.
View activity & pricesDC30002PF-06835919
PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been…
View activity & pricesDC23825BAY-293
BAY-293 is a potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction with an IC50 of 21 nM[1].
View activity & pricesDC11405MK-3903
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
View activity & pricesDC7783AF-353(Ro-4)
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
View activity & pricesDC7377BMY 7378
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
View activity & pricesDC8168Peficitinib（ASP015K,JNJ-54781532）
Peficitinib is an oral JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
View activity & pricesDC8275Apilimod
Apilimod is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.
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