DC2107Gemcitabine HCl (Gemzar,LY188011)
Gemcitabine hydrochloride is a DNA synthesis inhibitor with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM in BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells, respectively.
View activity & pricesDC Chemicals · Research reagentsDC2107 
DC21351
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DCAPI1056
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DC9777
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DC7958
DC1018
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DC26133
DC28040
DCAPI1051
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Small Molecule Research Tools
2816 products · Page 55 of 59
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DC2107DC21351MS4078
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) with a Kd of 19 nM for binding affinity to ALK[1].
View activity & pricesDC20228NSC617145(WRN inhibitor)
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145…
View activity & pricesDCAPI1056Nattokinase
Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1].
View activity & pricesDCAPI1064mixtures of three isomers (Gentamicins C1, C2, and C1(subA).
Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. It inhibits DNase I with an IC50 of…
View activity & pricesDC9777Regorafenib monohydrate（BAY 73-4506）
Regorafenib monohydrate is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
View activity & pricesDC21807VU 0465350
A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro…
View activity & pricesDC7958JNK-IN-8
JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively.
View activity & pricesDC1018GW-2580 (GW2580)
GW2580 is an orally bioavailable inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM.
View activity & pricesDC7621MI 2 (Menin-MLL Inhibitor)
MI-2 is a Menin-MLL interaction inhibitor with IC50 of 446±28 nM.
View activity & pricesDC26133Camostat mesylate
Camostat Mesylate(FOY305; FOY-S980) is a trypsin-like protease inhibitor.Camostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in…
View activity & pricesDC28040SBP1(spike-binding peptide 1)
SBP1(spike-binding peptide 1) is a first-in-class peptide binder to the SARS-CoV-2 spike protein. SBP1 specifically binds SARS-CoV-2-RBD with low nanomolar affinity. SBP1 to the RBD was determined to be 47 nM with the…
View activity & pricesDCAPI1051Arbidol HCl (Umifenovir)
Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane
View activity & pricesDC7211Neratinib (HKI-272)
Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.
View activity & pricesDC82030MYF-03-176
MYF-03-176 is an orally active and potent anticancer agent. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model via oral administration[1].
View activity & pricesDC23617NAB-14
NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C)…
View activity & pricesDC9150Tianeptine sodium salt
Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on…
View activity & pricesDC21317ML 086 (CID-1674999)
ML 086 is a potent, specific inhibitor of phosphatase PHOSPHO1 with IC50 of 139 nM, with no activity against TNAP (IC50>100 uM); a useful chemical tool to examine the functional role of this enzyme in skeletal…
View activity & pricesDC20890ChoK-α inhibitor CK37
A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site; significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of…
View activity & pricesDC20466MsbA inhibitor 1
MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane; causes mislocalization of LPS to the cell…
View activity & pricesDC26034NUC3373(Fosifloxuridine nafalbenamide)
NUC-3373 is a phosphoramidate-based prodrug of the monophosphate form of 5-fluoro-2'-deoxyuridine, the active metabolite of fluorouracil,an antimetabolite fluoropyrimidine analog of the pyrimidine nucleoside, with…
View activity & pricesDC7517THIACETAZONE
Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC…
View activity & pricesDCAPI1372Ciprofloxacin (Cipro)
Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
View activity & pricesDC21787UU-T03
UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM; downregulates…
View activity & pricesDC4121PSI6130
PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC50 of 0.6 μM.
View activity & pricesDC39816LDC195943(IMT1)
LDC195943(IMT1) is a highly specific inhibitor of human mitochondrial RNA polymerase (POLRMT).
View activity & pricesDC50013BC1618
BC1618 is a novel Fbxo48 inhibitor and prevent pAmpkα degradation with MEC (minimal efficacious concentration) of 0.6 μM.
View activity & pricesDC20558STOML3 inhibitor OB-1
A small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin;…
View activity & pricesDC70618MS177
MS177 (MS-177) is a potent and selective EZH2 degarder (PROTAC) based on EZH2 inhibitor C24 with CRBN ligand pomalidomide with DC50 of 0.2 uM in EOL-1 cells.MS177 effectively degraded cellular EZH2-PRC2, suppressed…
View activity & pricesDC26151Naloxone (hydrochloride)
Naloxone is an opioid inverse agonist drug used to counter the effects of opiate overdose.
View activity & pricesDCC3584NCGC00161856
NCGC00161856 is identified as the first small-molecule ligand and inverse agonist of the thyroid-stimulating hormone receptor (TSHR). It inhibits basal cAMP production in HEK-EM 293 cells that stably express TSHRs,…
View activity & pricesDC48349SP-8356
SP-8356, an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9…
View activity & pricesDC23481STD-101-D1
STD-101-D1 is a novel brain permeable, G protein-biased beta-1 adrenergic receptor (ADRB1) partial agonist with EC50 of 16.9 nM; engages very little beta-arrestin recruitment compared to the unbiased agonist…
View activity & pricesDC21050FN1-8
FN1-8 is a novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts…
View activity & pricesDC70709PRL-295
PRL-295 is a small molecule Keap1-Nrf2 protein–protein interaction inhibitor.PRL-295 binds to Keap1 in the cellular environment, disrupting its interaction with Nrf2, which leads to enhanced gene expression of the…
View activity & pricesDCW-017Vitamin C
For the detailed information of Vitamin C, the solubility of Vitamin C in water, the solubility of Vitamin C in DMSO, the solubility of Vitamin C in PBS buffer, the animal experiment（test） (test) of Vitamin C, the cell…
View activity & pricesDC20212Bisphenol A
Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking,…
View activity & pricesDC12668Citarinostat(ACY-241)
Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and…
View activity & pricesDCG-051Glutathione
For the detailed information of Glutathione, the solubility of Glutathione in water, the solubility of Glutathione in DMSO, the solubility of Glutathione in PBS buffer, the animal experiment（test） (test) of…
View activity & pricesDCG-004Glycyrrhizic acid
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
View activity & pricesDCD-0324-Hydroxycinnamic acid
For the detailed information of 4-Hydroxycinnamic acid, the solubility of 4-Hydroxycinnamic acid in water, the solubility of 4-Hydroxycinnamic acid in DMSO, the solubility of 4-Hydroxycinnamic acid in PBS buffer, the…
View activity & pricesDC21021Peptide P60
Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation,…
View activity & pricesDC73509S6821
S6821 (S 6821) is a potent and selective antagonist of the bitter taste receptor TAS2R8, exhibiting an IC50 value of 21 nM. It demonstrates high selectivity across a panel of 16 TAS2Rs, effectively reduces the…
View activity & pricesDCD-041Cholesterol
For the detailed information of Cholesterol, the solubility of Cholesterol in water, the solubility of Cholesterol in DMSO, the solubility of Cholesterol in PBS buffer, the animal experiment（test） (test) of…
View activity & pricesDC12320Betanin
In Vitro Betanin is a representative constituent of red beetroot betacyanins, could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM. Betanin also has anti-inflammatory, anti-proliferative effects,…
View activity & pricesDCAPI1349Simvastatin (Zocor)
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
View activity & pricesDC28667Azido-PEG5-acid
Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as the conjugate CPT-APO (CPT: Camptothecin).
View activity & pricesDC11818SCB-4380
SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis. SCB-4380 also strongly…
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