ML 086 (CID-1674999) chemical structure
Chemical structureResearch use only
CAT. NO. DC21317Featured

ML 086 (CID-1674999)

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Product overview

Description & Application

ML 086 is a potent, specific inhibitor of phosphatase PHOSPHO1 with IC50 of 139 nM, with no activity against TNAP (IC50>100 uM); a useful chemical tool to examine the functional role of this enzyme in skeletal mineralization and soft tissue ossification abnormalities.

ParameterValue
Chemical NameN,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzamide
CAS No.1177148-36-5
SynonymsML086;CID-1674999;ML-086;ML 086;CID 1674999;CID1674999
FormulaC16H14N2O2S
M.Wt298.36
SMILESC(N(C)C)(=O)C1=CC=CC(N2C(=O)C3=CC=CC=C3S2)=C1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ML 086 is a potent, specific inhibitor of phosphatase PHOSPHO1 with IC50 of 139 nM, with no activity against TNAP (IC50>100 uM); a useful chemical tool to examine the functional role of this enzyme in skeletal mineralization and soft tissue ossification abnormalities.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Stonich D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Bravo Y, et al. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4308-11. View Related Products by Target Protein Phosphatase/PTP

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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