Biological Activity
ML 086 is a potent, specific inhibitor of phosphatase PHOSPHO1 with IC50 of 139 nM, with no activity against TNAP (IC50>100 uM); a useful chemical tool to examine the functional role of this enzyme in skeletal mineralization and soft tissue ossification abnormalities.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
References 1. Stonich D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Bravo Y, et al. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4308-11. View Related Products by Target Protein Phosphatase/PTP
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.