DC60095NV-5138
NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 possesses rapid antidepressant effects[1][2].
View activity & pricesDC Chemicals · Research reagentsDC60095 
DC73744
DC73130
DC8935
DC43625
DC45758
DC74339
DC60279
DC1108
DC8746
DC67275
DC23181
DC47957
DC70526
DC8325
DC73683
DC73704
DC65705
DC9544
DC11456
DC46930
DC4110
DC74218
DC42587
DC73510
DC66611
DC10464
DC70648
DC22197
DC36079
DC70375
DC24079
DC67279
DC8162
DC60676
DC70785
DC40570
DC74576
DC7665
DC60790
DC60339
DC46946
DC44000
DC58312
DC11705
DC8392
DC70170
DCC0103
Small Molecule Research Tools
2816 products · Page 43 of 59
Browse 372 research categories
DC60095DC73744ADAM9i
ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM, promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
View activity & pricesDC73130AC-003
AC-003 is a novel, orally administered small-molecule inhibitor targeting receptor-interacting protein kinase 1 (RIPK1), demonstrating therapeutic potential for the treatment of idiopathic pulmonary fibrosis (IPF).
View activity & pricesDC8935Mitomycin C
Mitomycin C is an antitumor drug and antibiotic that shows extraordinary ability to inhibit DNA synthesis.
View activity & pricesDC43625Paprotrain
Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2)
View activity & pricesDC45758Revumenib
SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute…
View activity & pricesDC74339HRX-0233
HRX-0233 (HRX0233) is a potent and selective inhibitor of MAP2K4 (MKK4), a kinase involved in the stress-activated protein kinase (SAPK) signaling pathway. MAP2K4 plays a role in regulating cellular responses to…
View activity & pricesDC60279ART812
ART812 is a DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2].
View activity & pricesDC1108Laninamivir (CS-8958)
Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1].
View activity & pricesDC8746NSC319726
NSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.in vitro: For NSC319726, the effect was even greater…
View activity & pricesDC67275VU0364739
VU0364739 is a selective inhibitor of phospholipase D2 (PLD2) with an IC50 value of 22 nM. Phospholipase D (PLD) enzymes, including PLD1 and PLD2, are involved in various cellular processes, such as signal…
View activity & pricesDC23181(R)-GNE-140
(R)-GNE-140 (GNE-140) is a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively; displays no inhibition on malate MDH-1, MDH-2 (IC50>10 uM for…
View activity & pricesDC47957LSN3318839
LSN3318839 is an orally efficacious positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R).
View activity & pricesDC70526JP-11646
JP-11646 is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively; shows less potency for other kinases in a kinase selectivity panel; exhibits 4-760-fold…
View activity & pricesDC8325Ellipticine
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
View activity & pricesDC73683LTGO-33
LTGO-33 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.8 with IC50 of 44 nM (hNaV1.8), 600-fold selectivity against NaV1.1-NaV1.7 and NaV1.9.
View activity & pricesDC73704AD-5591
AD-5591 (AD5591) is a potent, selective, new generation small molecule ALDH2 activator, has the improved biological activities and pharmacological properties compared to Alda-1. AD-5591 (100 μM) significantly increases…
View activity & pricesDC65705Cagrilintide
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant…
View activity & pricesDC9544Stenabolic (SR9009)
SR9009 is a REV-ERBα/β agonist with IC50s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively.
View activity & pricesDC11456MeO-Suc-Arg-Pro-Tyr-pNA
S-2222 is chromogenic substrate for factor Xa. When catalyzed by factor Xa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm wavelength.Chromogenic substrate S-2222 can be used in many…
View activity & pricesDC46930Sunvozertinib
Sunvozertinib is a potent inhibitor targeting the ErbB family of receptor tyrosine kinases, including EGFR (Epidermal Growth Factor Receptor) and Her2 (Human Epidermal Growth Factor Receptor 2), as well as BTK…
View activity & pricesDC4110AZD-2281 (Olaparib)
Olaparib (AZD2281;KU0059436) is a potent and oral PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively.
View activity & pricesDC74218UT-59
UT-59 is a specific inhibitor that targets the cholesterol-sensing membrane protein Scap (SREBP cleavage-activating protein). It functions by binding to Scap's cholesterol-binding site, which prevents Scap from…
View activity & pricesDC42587Bexin-1
Bexin-1 is a specific inhibitor that targets Munc13-4, a protein critical for regulated exocytosis, particularly in secretory cells such as immune cells (e.g., cytotoxic T lymphocytes, mast cells) and neuroendocrine…
View activity & pricesDC73510Org 274179-0
Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.
View activity & pricesDC66611PF-07328948
PF-07328948 is a first-in-class branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with IC50 of 15 nM and shows a high degree selectivity over a number of kinases and other off-targets. PF-07328948 is the…
View activity & pricesDC10464PT2385
PT-2385 is a selective HIF-2α antagonist with a Ki of less than 50 nM.
View activity & pricesDC70648NH-23-C2
NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine…
View activity & pricesDC22197PZ09(PKC-9)
PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of…
View activity & pricesDC36079Artemisitene
Artemisitene is an antimalarial agent and the oxidized form of Artemisinin. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinic acid, Artemisinin B,…
View activity & pricesDC70375E722-2648
E722-2648 (Compound C-1) is a novel specific and competitive small molecule β-catenin/BCL9 interaction inhibitor with ITC KD of 1.05 uM and IC50 of 9 uM, blocks oncogenic Wnt signaling and disrupts cholesterol…
View activity & pricesDC24079DG-172 dihydrochloride
DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties; inhibits agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor…
View activity & pricesDC67279Rhobo6
Rhobo6 is a fluorescent glycan-binding probe optimized for live-cell imaging and in vivo tracking of glycoconjugates. It exhibits pH-dependent binding (pKa ~5-7), high photostability, and minimal cytotoxicity.…
View activity & pricesDC8162Dasotraline(SEP-225289) free base
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
View activity & pricesDC60676MRT6160
MRT-6160 represents a groundbreaking molecular glue degrader designed to selectively target VAV1, achieving its proteasomal degradation with a DC50 value of 7 nM. This innovative compound showcases its unique mechanism…
View activity & pricesDC70785SKLB-03176
SKLB-03176 (SKLB03176) is a potent, selective, covalent EZH2 inhibitor with IC50 of 47 nM, covalently binds to the SAM pocket of EZH2.SKLB-03176 showed good inhibitory activity against mutations EZH2 Y641F, EZH2 Y641N,…
View activity & pricesDC40570KY19382
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction…
View activity & pricesDC74576Fluorofurimazine
Fluorofurimazine is an advanced furimazine derivative with enhanced aqueous solubility, allowing for greater signal output compared to furimazine in bioluminescence imaging. This compound supports higher substrate…
View activity & pricesDC7665Gandotinib(LY2784544)
Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM. Gandotinib (LY2784544) also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC50 of 4, 25, 32, 44, and 95 nM.
View activity & pricesDC60790DesMEM AZD4694
DesMEM AZD4694（AZD4694 Precursor 1）is the precursor of 18F AZD4694 for the synthesis of 18F AZD4694, an amyloid-β imaging ligand with high affinity for amyloid-β plaques.
View activity & pricesDC60339Cephalofurimazine (CFz)
Cephalofurimazine (CFz) is a NanoLuc substrate optimized for enhanced brain performance. When paired with Antares luciferase, it generates over 20 times more signal from the brain compared to the traditional…
View activity & pricesDC46946PF-07220060
PF-07220060 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
View activity & pricesDC44000J-2156 TFA
J-2156 TFA is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 TFA is used for the relief of…
View activity & pricesDC58312Divarasib
GDC-6036 is a novel oral KRAS G12C inhibitor.
View activity & pricesDC11705GPR30 inhibitor G1
A potent and selective GPER/GPR30 agonist with Ki of 11 nM, EC50 of 2 nM; displays no activity at ERα and ERβ at concentrations up to 10 uM; increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7…
View activity & pricesDC8392BQ-123
BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced…
View activity & pricesDC70170AC3573
AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3.AC3573 abrogates HER2–HER3 signalling in cells and is more specific for HER3, inhibits NRG (heregulin)-induced HER3 phosphorylation with IC50 of…
View activity & pricesDCC0103(R)-N-Desmethyl PK11195
Precursor for (R)-N-Methyl-11C-PK11195
View activity & prices