Sunvozertinib chemical structure
Chemical structureResearch use only
CAT. NO. DC46930Featured

Sunvozertinib

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Product overview

Description & Application

Sunvozertinib is a potent inhibitor targeting the ErbB family of receptor tyrosine kinases, including EGFR (Epidermal Growth Factor Receptor) and Her2 (Human Epidermal Growth Factor Receptor 2), as well as BTK (Bruton's Tyrosine Kinase). It exhibits particularly strong activity against mutant forms of these kinases, which are often associated with resistance to existing therapies in cancers such as non-small cell lung cancer (NSCLC).

The IC50 values (half-maximal inhibitory concentr.

ParameterValue
Chemical NameSunvozertinib
CAS No.2370013-12-8
Synonymssunvozertinib;L1Q2K5JYO8;Sunvozertinib [INN];GTPL11672;Example 52 [WO2019149164A1];2-Propenamide, N-(5-((4-((5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl)amino)-2-pyrimidinyl)amino)-2-((3R)-3-(dimethylamino)-1-pyrrolidinyl)-4-methoxyphenyl)-;N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide;CHEMBL5314564;ASYM-122507;2370013-12-8;EX-A6612;(R)-N-(5-((4-((5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide;Sunvozertinib [WHO-DD];DZ'0586;UNII-L1Q2K5JYO8;D12506;DZ00000586;DA-67862;CS-0204146;Sunvozertinib (USAN/INN);HY-132842;A-1801;BDBM536927;DZD-9008;US11896597, Compound 77;A1801;2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-;DZD 9008;EGFR/HER2 Inhibitor DZD9008;G18377;MS-30456;DZ-0586;DZD9008;SUNVOZERTINIB [USAN];N-(5-((4-(5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino)pyrimidin-2-yl)amino)-2-((3R)-3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)prop-2-enamide;Example 52 (WO2019149164A1);2-Propenamide, N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1- methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-;US11896597, Compound 52;DZ0586;GLXC-25829;SCHEMBL21232131;N-{5-[(4-{[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino}pyrimidin-2-yl)amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl}prop-2-enamide
FormulaC29H35ClFN7O3
M.Wt584.084708452225
SMILESClC1C(=CC(=C(C=1)NC1=CC=NC(=N1)NC1C(=CC(=C(C=1)NC(C=C)=O)N1CC[C@H](C1)N(C)C)OC)C(C)(C)O)F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Sunvozertinib is a potent inhibitor targeting the ErbB family of receptor tyrosine kinases, including EGFR (Epidermal Growth Factor Receptor) and Her2 (Human Epidermal Growth Factor Receptor 2), as well as BTK (Bruton's Tyrosine Kinase). It exhibits particularly strong activity against mutant forms of these kinases, which are often associated with resistance to existing therapies in cancers such as non-small cell lung cancer (NSCLC).

The IC50 values (half-maximal inhibitory concentr.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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