NH-23-C2 chemical structure
Chemical structureResearch use only
CAT. NO. DC70648Featured

NH-23-C2

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TotalUS$750
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Product overview

Description & Application

NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.

ParameterValue
Chemical NameNH-23-C2
SynonymsCaspase-2 inhibitor NH-23-C2
FormulaC43H51N5O13
M.Wt845.903
SMILESO=C(O)CCC[C@H](NC([C@H]1NC2=C(C=CC=C2)C1)=O)C(N[C@@H]([C@H](OCC3=CC=CC=C3)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(COC(C4=C(C)C=CC=C4C)=O)=O)=O)=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1. Marcin Poreba, et al. Cell Death Differ. 2019 Dec;26(12):2695-2709.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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