PT2385 chemical structure
Chemical structureResearch use only
CAT. NO. DC10464Featured

PT2385

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TotalUS$2,500
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Product overview

Description & Application

PT-2385 is a selective HIF-2α antagonist with a Ki of less than 50 nM.

ParameterValue
Chemical NamePT 2385,PT-2385
CAS No.1672665-49-4
SynonymsPT 2385,PT-2385
FormulaC17H12F3NO4S
M.Wt383.34
SMILESCS(=O)(=O)C1=C2[C@@H](C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

PT-2385 is a selective HIF-2α antagonist with a Ki of less than 50 nM.

In Vitro

PT-2385 (PT2385) is a selective antagonist of HIF-2 over HIF-1. PT-2385 is inactive for HIF-1α[1].

In Vivo

PT-2385 (PT2385) inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT-2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT-2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT-2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31)[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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