DC7483PPQ-102
PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC50 of ~90 nM.
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DC7100
DC7039
DC4128
DC9276
DC7531
DC42510
CFTR
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All small molecule research tools
DC7483DC7100CFTRinh 172
CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibited CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
View activity & pricesDC7039CFTR Inhibitor II
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
View activity & pricesDC4128Ivacaftor (VX-770)
Ivacaftor is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
View activity & pricesDC9276KM 11060
KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing…
View activity & pricesDC7531Tezacaftor(VX661)
VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface.
View activity & pricesDC42510Ivacaftor-d9
Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog…
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