KM 11060 chemical structure
Chemical structureResearch use only
CAT. NO. DC9276Featured

KM 11060

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TotalUS$300
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Product overview

Description & Application

KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]

ParameterValue
Chemical Name7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline
CAS No.774549-97-2
SynonymsKM 11060;7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE;7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline;7-Chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline;7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazino}quinoline;KM-11060;Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-;KM11060;7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline;7-chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)quinoline;7-chloro-4-{4-[(4-chlorobenzene)sulfonyl]piperazin-1-yl}quinoline;Oprea1_790000;GTPL4234;BCP17185
FormulaC19H17Cl2N3O2S
M.Wt422.3282
SMILESClC1C([H])=C([H])C2C(C=1[H])=NC([H])=C([H])C=2N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(C1C([H])=C([H])C(=C([H])C=1[H])Cl)(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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