DC Chemicals · Product datasheet

KM 11060 — Datasheet

CAT. NO. DC9276

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ParameterValue
Chemical Name7-Chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline
CAS No.774549-97-2
SynonymsKM 11060;7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE;7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline;7-Chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline;7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazino}quinoline;KM-11060;Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-;KM11060;7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline;7-chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)quinoline;7-chloro-4-{4-[(4-chlorobenzene)sulfonyl]piperazin-1-yl}quinoline;Oprea1_790000;GTPL4234;BCP17185
FormulaC19H17Cl2N3O2S
M.Wt422.3282
SMILESClC1C([H])=C([H])C2C(C=1[H])=NC([H])=C([H])C=2N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(C1C([H])=C([H])C(=C([H])C=1[H])Cl)(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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