DC7738CAY10683(Santacruzamate A)
Santacruzamate A is a potent and selective histone deacetylase inhibitor.
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Small Molecule Research Tools
2816 products · Page 26 of 59
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DC7738DC8660BML-210(CAY10433)
BML-210 is a novel HDAC inhibitor, and its mechanism of action has not been characterized.
View activity & pricesDC8478M 344
M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.
View activity & pricesDC9273SC-66
SC66 is a novel Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.
View activity & pricesDC7962HPOB
HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.target: HDAC6 [1]IC 50: 56nM [1]In vitro: HPOB causes growth inhibition of…
View activity & pricesDC9733GSK583
GSK583 is a highly potent and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM.
View activity & pricesDC7533wiki4
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
View activity & pricesDC7065Tivantinib (ARQ 197)
Tivantinib is a novel and highly selective c-Met tyrosine kinase inhibitor with Ki of 355 nM.
View activity & pricesDC20023TP0463518
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2…
View activity & pricesDC8466CPI-169 (racemate）
CPI-169 racemate is the racemate form of CPI-169, which is a novel and potent EZH2 inhibitor with IC50 <1 nM(inhibition of the catalytic activity of PRC2); decreases cellular levels of H3K27me3 with an EC50 of 70 nM,…
View activity & pricesDC41869PAMP-12(human, porcine)
PAMP-12(human, porcine) is a major component of immunoreactive (ir)-PAMP, is processed from the adrenomedullin precursor, is a potent hypotensive peptide and participates in cardiovascular control.
View activity & pricesDC41966CSP1
CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating…
View activity & pricesDC8701Fmoc-Val-Cit-PAB-PNP
Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).
View activity & pricesDC10724AZD2098
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor, used for asthma research.
View activity & pricesDC8062BX517
BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
View activity & pricesDC9504YH239-EE
YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the…
View activity & pricesDC8397AMG 925
AMG 925 is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
View activity & pricesStructure information available on request
DC11332Degarelix (acetate)
Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
View activity & pricesStructure information available on request
DC11152BLU-782
ALK2-IN-1 is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1, Compound 876, has an IC50 of <10 nM[1].
View activity & pricesDC8190Ravidasvir hydrochloride (PPI-668)
Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.
View activity & pricesDC10827THZ531
THZ531 is a covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively.
View activity & pricesDC11900Lazertinib
Lazertinib is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung…
View activity & pricesStructure information available on request
DC8940Raltitrexed
Raltitrexed is an antimetabolite drug used in chemotherapy, acting by inhibiting thymidylate synthase.
View activity & pricesDC10741HAMNO (NSC111847)
HAMNO is a novel protein interaction inhibitor of replication protein A (RPA).
View activity & pricesDC11278Fevipiprant
Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of…
View activity & pricesDC9706ABT-639
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
View activity & pricesDC9915PF04995274,PF 04995274
PF-04995274 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM), and has an…
View activity & pricesDC60568RMC-9805（Zoldonrasib）
RMC-9805 is a first-in-class, mutant-selective, covalent and orally bioavailable KRAS-G12D(ON) inhibitor. RMC-9805 exhibits direct anti-tumor effects and indirectly transformed the TME through inhibition of cancer…
View activity & pricesDC22537SMAP
SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A; inhibits the…
View activity & pricesDC7048Ricolinostat (ACY-1215)
Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor, with an IC50 of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50s of 58, 48, and 51 nM, respectively.
View activity & pricesDC11312Xanthine amine congener
Xanthine amine congener (XAC) is a non-selective adenosine receptor antagonist with Kb values of 83, 25, and 15 nM for rat PC12 cells, human platelets that endogenously express adenosine A2A receptors, and rat fat…
View activity & pricesDC7711Losmapimod
Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively.
View activity & pricesDC11355MMP-3 Inhibitor
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.
View activity & pricesDC10722CGP-71683A
CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
View activity & pricesDC11056Baloxavir marboxil
Baloxavir marboxil is a prodrug of S-033447. S-033447 is a small molecule inhibitor of the cap-dependent endonuclease of influenza A and B viruses.
View activity & pricesDC21786UU-T02
UU-T02 is a novel potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; displays 63-fold and 175-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions,…
View activity & pricesDC9602Balaglitazone
Balaglitazone is a selective partial PPARγ agonist with an EC50 of 1.351 μM for human PPARγ.
View activity & pricesDC7655APD668
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.Chronic treatment withAPD668 showed for the first time that blood glucose and glycated hemoglobin (HbA1c) levels…
View activity & pricesDC2013Bafetinib (INNO-406)
Bafetinib is a Lyn and Bcr-Abl tyrosine kinase inhibitor with potential antineoplastic activity.
View activity & pricesDC10769CU-CPT-9b
CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.
View activity & pricesDC7812GSK923295
GSK-923295 is a special, allosteric inhibitor of CENP-E kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.
View activity & pricesDC9308Doravirine (MK-1439)
Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus (95% inhibitory concentration 19 nM, 50% human serum).
View activity & pricesDC7668CL-387785
CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.
View activity & pricesDC8274Dihydroethidium
Dihydroethidium(Hydroethidine; PD-MY 003) is a superoxide indicator; exhibits blue-fluorescence in the cytosol until oxidized, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red.
View activity & pricesDC11397TAK-779
TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in…
View activity & pricesDC7070AT9283
AT9283 is a multitargeted kinase inhibitor which potently inhibits aurora kinase A/B, JAK2/3 (IC50=1.2 nM, 1.1 nM).
View activity & pricesDC5167Ceritinib(LDK378)
Ceritinib (LDK378) is a potent and specific ALK inhibitor with an IC50 of 0.2 nM.
View activity & pricesDC10746KDU691
KDU691 is a PI4K inhibitor.
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