Chemical structureResearch use only

CAT. NO. DC7668Featured

CL-387785

Name: CL-387785
Brand: DC Chemicals
SKU: DC7668
Price: 400.0 USD

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TotalUS$400

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Product overview

Description & Application

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.

Parameter	Value
Chemical Name	N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
CAS No.	194423-06-8
Synonyms	2-Butynamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-;CL-387785;CL-387785 (EKI-785);EKI-785;N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide;CL387785;EKI785;WAY-EKI 785;N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl)-2-butynamide;EKB 785;CL-387;CL-38875;EKI-785 CL-38875;N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide;N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-2-ButynaMide CL-387785;N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide;B4W27J1Z8B;N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynamide;2-Butynamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-;C18H13BrN4O;N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynami
Formula	C18H13BrN4O
M.Wt	381.226
SMILES	BrC1=C([H])C([H])=C([H])C(=C1[H])N([H])C1C2C([H])=C(C([H])=C([H])C=2N=C([H])N=1)N([H])C(C#CC([H])([H])[H])=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheet Request COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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