DC Chemicals · Product datasheet

CL-387785 — Datasheet

CAT. NO. DC7668

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ParameterValue
Chemical NameN-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
CAS No.194423-06-8
Synonyms2-Butynamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-;CL-387785;CL-387785 (EKI-785);EKI-785;N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide;CL387785;EKI785;WAY-EKI 785;N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl)-2-butynamide;EKB 785;CL-387;CL-38875;EKI-785 CL-38875;N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide;N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-2-ButynaMide CL-387785;N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide;B4W27J1Z8B;N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynamide;2-Butynamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-;C18H13BrN4O;N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynami
FormulaC18H13BrN4O
M.Wt381.226
SMILESBrC1=C([H])C([H])=C([H])C(=C1[H])N([H])C1C2C([H])=C(C([H])=C([H])C=2N=C([H])N=1)N([H])C(C#CC([H])([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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