DC10871MTX211
MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases.
View activity & pricesDC Chemicals · Research reagentsDC10871 
DC5181
DC5154
DC1068
DC1054
DC7228
DC5072
DC5068
DC10754
DC7141
DC8380
DC7516
DC9747
DC10461
DC9879
DC9708
DC3133
DC7234
DC8335
DC9829
DC8760
DC8004
DC10219
DC28978
DC11906
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DC7953
DC10153
DC8257
DC10019
DC1096
DC7348
PI3K
32 products · Page 1 of 1
All small molecule research tools
DC10871DC5181Voxtalisib Analogue
XL-765, also known as SAR245409, is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases…
View activity & pricesDC5154BKM120 (NVP-BKM120, Buparlisib)
NVP-BKM120 is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively.
View activity & pricesDC1068XL147 analogue(PI3K inhibitor X)
Pilaralisib analogue (XL147 analogue) is a representative and selective PI3Kα inhibitor extracted from patent WO2012006552A1, Compound 147 in Table 1.
View activity & pricesDC1054GDC0941(Pictilisib)
GDC-0941 (Pictilisib) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
View activity & pricesDC7228PF-04691502
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR. PF-04691502 binds to human PI3Kα, β, δ, γ and mTOR with Kis of 1.8, 2.1, 1.6, 1.9 and 16 nM, respectively.
View activity & pricesDC5072Duvelisib (IPI-145, INK1197)
Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.
View activity & pricesDC5068Idelalisib (CAL-101,GS-1101)
Idelalisib (CAL-101) is a highly selective and potent p110δ inhibitor with an IC50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes.
View activity & pricesDC10754LX2343
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
View activity & pricesDC7141Omipalisib
Omipalisib (GSK2126458) is a highly selective and potent inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.
View activity & pricesDC8380AZD8186
AZD8186 is a PI3K inhibitor, which potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC5050=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
View activity & pricesDC7516TG100-115
TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively.
View activity & pricesDC9747PIK-III
Vps34-PIK-III is a potent and selective inhibitor of VPS34 with an IC50 of 18 nM.
View activity & pricesDC10461Autophinib
Autophinib is a potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.
View activity & pricesDC9879AZD8835
AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50s of 6.2 and 5.7 nM, respectively.
View activity & pricesDC9708Paxalisib (GDC-0084)
GDC-0084 is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.
View activity & pricesDC3133NVP-BGT226 (BGT226）
NVP-BGT226 is a potent pan-class I PI3K and mTOR catalytic inhibitor with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ.
View activity & pricesDC7234PIK-294
PIK-294 is a potent p110δ-selective inhibitor with an IC50 of 10 nM.
View activity & pricesDC8335PQR-309(Bimiralisib)
Bimiralisib is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. Bimiralisib is…
View activity & pricesDC9829IPI-549
IPI549 is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM.
View activity & pricesDC8760Acalisib
Acalisib is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM.
View activity & pricesDC8004AZD6482
AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM.
View activity & pricesDC10219LY3023414
LY3023414 potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively.…
View activity & pricesDC28978Copanlisib dihydrochloride (BAY 80-6946)
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ,…
View activity & pricesDC11906Parsaclisib
Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
View activity & pricesDC7238Gedatolisib(PKI-587)
Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PKI-587 is equally effective in both complexes of mTOR, mTORC1 and mTORC2.
View activity & pricesDC7953GNE-493
GNE-493 is a potent, selective, and orally available dual pan-PI3-kinase/mTOR inhibitor with IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.
View activity & pricesDC10153GDC-0077
GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I.
View activity & pricesDC8257GNE 477
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
View activity & pricesDC10019VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.
View activity & pricesDC1096PIK90
PIK-90 is a DNA-PK and PI3K inhibitor, which inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
View activity & pricesDC73483-Methyladenine
3-Methyladenine is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
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